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프로필티오우라실

프로필티오우라실
프로필티오우라실 구조식 이미지
카스 번호:
51-52-5
한글명:
프로필티오우라실
동의어(한글):
프로필티오우라실;프로필싸이오우라실
상품명:
Propylthiouracil
동의어(영문):
T 72;6-PTU;PROPYCIL;PROPACIL;PROCASIL;NSC 6498;PROTHYRAN;NSC 70461;Prothycil;Protiural
CBNumber:
CB9777662
분자식:
C7H10N2OS
포뮬러 무게:
170.23
MOL 파일:
51-52-5.mol

프로필티오우라실 속성

녹는점
218-220 °C(lit.)
밀도
1.1880 (rough estimate)
굴절률
1.5960 (estimate)
인화점
300 °C
저장 조건
Refrigerator
용해도
1.1g/l
산도 계수 (pKa)
pKa 7.8; 8.3 (Uncertain)
물리적 상태
neat
수소이온지수(pH)
6-7.5 (5g/l, H2O, 20℃)(slurry)
수용성
1.1 g/L
Merck
14,7869
BRN
130039
안정성
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
CAS 데이터베이스
51-52-5(CAS DataBase Reference)
NIST
Tegretol(51-52-5)
EPA
4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo- (51-52-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-40
안전지침서 36/37-45
WGK 독일 3
RTECS 번호 YR1400000
위험 참고 사항 Harmful/Irritant
HS 번호 29335995
유해 물질 데이터 51-52-5(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 1250 mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오

프로필티오우라실 MSDS


2-Mercapto-6-propylpyrimid-4-one

프로필티오우라실 C화학적 특성, 용도, 생산

화학적 성질

White Crystalline Powder

화학적 성질

White crystalline solid or powder. Odorless. Bitter taste.

용도

Antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen

용도

antibacterial

정의

ChEBI: A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.

일반 설명

Odorless white crystalline powder of starch-like appearance. Bitter taste. Saturated solution is neutral or slightly acid to litmus.

일반 설명

Propylthiouracil, 6-propyl-2-thiouracil (Propacil), is a stable, white, crystalline powderwith a bitter taste. It is slightly soluble in water but readilysoluble in alkaline solutions (salt formation).

공기와 물의 반응

Sensitive to light. May be sensitive to prolonged exposure to air. Insoluble in water.

반응 프로필

Propylthiouracil is incompatible with strong oxidizing agents, strong acids and strong bases. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . When reduced will produce hydrogen sulfide.

위험도

Possible carcinogen.

화재위험

Flash point data for Propylthiouracil are not available; however Propylthiouracil is probably combustible.

Clinical Use

Propylthiouracil is useful in the treatment of hyperthyroidism.There is a delay in appearance of its effects because propylthiouracildoes not interfere with the activity of thyroid hormonesalready formed and stored in the thyroid gland. Thislag period may vary from several days to weeks, dependingon the condition of the patient. The need for three equallyspaced doses during a 24-hour period is often stressed, butevidence now indicates that a single daily dose is as effectiveas multiple daily doses in the treatment of most hyperthyroidpatients.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects: agranulocytosis, hepatitis, jaundice. Human teratogenic effects by ingestion: developmental abnormalities of the endocrine system and changes in newborn viability. Human and experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also MERCAPTANS.

잠재적 노출

Medication (antihyperthyroid; thyroid inhibitor) with human and veterinary applications.

Carcinogenicity

Propylthiouracil is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

운송 방법

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify propacil by recrystallisation from H2O (soluble in 900 parts at 20o, and 100 parts at 100o). UV, MeOH: max 277nm. [Anderson et al. J Am Chem Soc 67 2197 1945, Vanderhaegue Bull Soc Chim Belg 59 689 1950, Beilstein 24 III/IV 1333.]

비 호환성

This chemical is probably combustible; it’s dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanga- nates, perchlorates, chlorine, bromine, fluorine, etc.); con- tact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Forms complexes with divalent metals. Reacts with sulfhydryl-oxidizing agents . Sensitive to light and may be sensitive to air.

폐기물 처리

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding to trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely pack- age the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

법규

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Environmental Protection Agency (EPA)
Resource Conservation and Recovery Act
Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
Propylthiouracil is a prescription drug subject to specific labeling requirements.

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