Acitretin manufacturers and suppliers

Acitretin suppliers

Properties

Melting point:: 228-230°C

Boiling point:: 404.46°C (rough estimate)

Density: 1.1348 (rough estimate)

refractive index: 1.4700 (estimate)

storage temp.: -20°C

solubility: Practically insoluble in water, sparingly soluble in tetrahydrofuran, slightly soluble in acetone and in ethanol (96 per cent), very slightly soluble in cyclohexane.

form: powder

pka: 4.72±0.33(Predicted)

color: Light yellow to yellow

λmax: 352nm(MeOH)(lit.)

Merck: 14,112

Stability:: LIGHT SENSITIVE

InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+

InChIKey: IHUNBGSDBOWDMA-AQFIFDHZSA-N

SMILES: C(O)(=O)/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)C=C(OC)C(C)=C1C

CAS DataBase Reference: 55079-83-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Danger

Hazard statements: H315-H319-H360-H410

Precautionary statements: P201-P273-P302+P352-P305+P351+P338-P308+P313

PPE: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T,N

Risk Statements: 61-36/38-50/53

Safety Statements: 53-26-45-60-61-37/39

RIDADR: UN 3077 9/PG 3

WGK Germany: 3

RTECS: RA8460000

F: 8-10-21

HazardClass: 9

PackingGroup: III

HS Code: 2918992090

Storage Class: 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2

Hazardous Substances Data: 55079-83-9(Hazardous Substances Data)

Toxicity: LD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978)

Use

Acitretin, a retinol derivative, was introduced in 1989 for the treatment of severe psoriasis. By the end of 1990, acitretin was confirmed to be metabolized in part to etretinate. Marketing authorization was suspended temporarily in France while the product information was modified to conform to the recommendations issued by the Committee for Proprietary Medicinal Products of the European Communities. Acitretin remains registered in several countries. See also WHO comment for etretinate.

You can find Acitretin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.