Chelerythrine manufacturers and suppliers

Chelerythrine suppliers

Properties

Melting point:: 195-205°C

Boiling point:: 496.37°C (rough estimate)

Density: 1.2985 (rough estimate)

refractive index: 1.5614 (estimate)

storage temp.: Desiccate at -20°C

solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly）

form: Solid

color: Light Yellow to Dark Orange

Stability:: Hygroscopic

InChI: InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1

InChIKey: LLEJIEBFSOEYIV-UHFFFAOYSA-N

SMILES: C[N+]1=CC2=C(C(OC)=CC=C2C2C=CC3C=C4OCOC4=CC=3C1=2)OC

LogP: -0.401 (est)

CAS DataBase Reference: 34316-15-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS06,GHS07

Signal word: Danger

Hazard statements: H300-H315-H319-H335

Precautionary statements: P261-P264-P301+P310+P330-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 20/21/22

Safety Statements: 36/37

Use

Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad.

You can find Chelerythrine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the Germany here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.