Rotundine manufacturers and suppliers

Rotundine suppliers

Properties

Melting point:: 140-1°C

storage temp.: Hygroscopic, Refrigerator, under inert atmosphere

solubility: Chloroform (Slightly), Methanol (Slightly)

form: Solid

color: White to Off-White

InChI: InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3

InChIKey: AEQDJSLRWYMAQI-UHFFFAOYSA-N

SMILES: C12CC3=C(C(OC)=C(OC)C=C3)CN1CCC1C=C(OC)C(OC)=CC2=1

LogP: 0.591 (est)

CAS DataBase Reference: 10097-84-4(CAS DataBase Reference)

Safety Information

Safety Statements: 24/25

HS Code: 29339900

Use

Tetrahydropalmatine (THP) is an isoquinoline alkaloid found in in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda (Qian Jin Teng). These plants exhibits analgesic, antinociceptive, anxiolytic, antidepressant, and anti-parasitic activities, and have traditional uses in Chinese herbal medicine. In particular, the levo isomer of THP (l-THP) appears to contribute to many of the therapeutic effects of these herbs. Notably, the dextro isomer of THP has distinct pharmacological actions that include depletion of monoamines and may contribute to the toxicology profile of THP-containing preparations or racemic mixtures of the compound. In addition to serving as an active constituent in traditional Chinese herbal preparations, purified or synthetic l-THP is approved for use and available as Rotundine or Rotundin in China, where l-THP has been used as an analgesic and sedative for more than 40 years.

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