Terbinafine Hydrochloride manufacturers and suppliers

Terbinafine Hydrochloride suppliers

Properties

Melting point:: 204-208°C

storage temp.: 15-25°C

solubility: methanol: soluble50mg/mL

form: powder

color: white

Merck: 14,9156

BCS Class: 1

InChI: InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

InChIKey: BWMISRWJRUSYEX-SZKNIZGXSA-N

SMILES: C12C=CC=CC1=CC=CC=2CN(C)C/C=C/C#CC(C)(C)C.Cl

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H315-H319-H335-H410

Precautionary statements: P261-P264-P271-P273-P302+P352-P305+P351+P338

Hazard Codes: Xi,N

Risk Statements: 36/37/38-50/53

Safety Statements: 26-36/37/39-61-60

RIDADR: UN 3077 9/PG 3

WGK Germany: 3

RTECS: QJ8600100

HS Code: 29214990

Toxicity: LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)

Use

According to reports in the literatures, after 250 mg of Terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. The absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. The combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. Terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. The metabolites after the bioconversion have no antifungal activity, then discharged through urine. The half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. But the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.

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