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Terbinafine Hydrochloride

Dermatologist Broad-spectrum Antifungal Drugs Pharmacokinetics Indications Usage and Dosage Chemical Properties Usage
Terbinafine Hydrochloride
Terbinafine Hydrochloride structure
CAS No.
78628-80-5
Chemical Name:
Terbinafine Hydrochloride
Synonyms
Brican;Bricar;Bricyn;Kelger;Afogan;D02219;lamosil;Brethin;Muzonal;Terbina
CBNumber:
CB9767492
Molecular Formula:
C21H26ClN
Formula Weight:
327.89
MOL File:
78628-80-5.mol

Terbinafine Hydrochloride Properties

Melting point:
204-208°C
storage temp. 
-20°C Freezer
solubility 
methanol: soluble50mg/mL
form 
powder
color 
white
Merck 
14,9156
InChIKey
BWMISRWJRUSYEX-SZKNIZGXSA-N
CAS DataBase Reference
78628-80-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N
Risk Statements  36/37/38-50/53
Safety Statements  26-36/37/39-61-60
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  QJ8600100
Toxicity LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Terbinafine Hydrochloride price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1298 Terbinafine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 78628-80-5 1g $62.3 2018-11-13 Buy
Sigma-Aldrich 1643496 Terbinafine hydrochloride United States Pharmacopeia (USP) Reference Standard 78628-80-5 200mg $352.8 2018-11-13 Buy
TCI Chemical D2049 trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride >98.0%(HPLC)(T) 78628-80-5 1g $105 2018-11-22 Buy
TCI Chemical D2049 trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride >98.0%(HPLC)(T) 78628-80-5 5g $352 2018-11-22 Buy
Cayman Chemical 10011619 Terbinafine (hydrochloride) ≥98% 78628-80-5 100mg $59 2018-11-19 Buy

Terbinafine Hydrochloride Chemical Properties,Uses,Production

Dermatologist Broad-spectrum Antifungal Drugs

Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It is developed by Swiss Novartis in the 1980 s, and appeared in the market of UK for the first time in 1991. Approved by FDA of the United States for OTC drugs in 1996, and appeared in the market of the United States in the same year. At present, the drug is been sold in more than 90 countries of the word. It can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. Suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis.
Terbinafine hydrochloride entered the the first batch of country announced OTC directory in 2000. This product belongs to antifungal drugs. It has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.

Pharmacokinetics

According to reports in the literatures, after 250 mg of Terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. The absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. The combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. Terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. The metabolites after the bioconversion have no antifungal activity, then discharged through urine. The half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. But the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.

Indications

1.Skin, hair and nail infection caused by Btrichophyta (white hair versicolor bacterium, Trichophyton mentagrophytes, Trichophyton verrucosum, trichophyton tonsurans and Trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect.
2.Skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.).
3.Onychomycosis (nail fungus infection) caused by molds.

Usage and Dosage

Local external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. Ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks.
Oral: 0.25 grams each time for adult, once per day, period of treatment is as follows:
Skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2~6 weeks; Ringworm of the body, tinea, 2~4 weeks.
Skin candidiasis: 2~4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing.
Hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children.
Onychomycosis: The most treatment course of patients is 6 weeks to three months. Young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour.
In other cases, the treatment is usually 3 months. Some patients, especially whose thumb (toe) infected, may take 6 months or longer. The treatment may take more than 3 months if the nail grew slowly in the first week. In healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.

Chemical Properties

White crystalline powder. Melting point is 204-208 oC.

Usage

Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. It can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc.
This information is edited by ChemicalBook Xiao Nan.

Description

Terbinafine hydrochloride is the first orally active allylamine antifungal with 30-fold greater antifungal activity than naftifine. The compound is indicated for the treatment of ringworm and fungal nail infections. Terbinatine hydrochloride acts on a single fungal enzyme, squalene epoxidase, interfering with the biosynthesis of ergosterols in cell membranes. Unlike other antifungal agents, it does not inhibit cytochrome P450 enzymes.

Chemical Properties

Crystalline Powder

Originator

Sandoz (Switzerland)

Uses

An orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.

Uses

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Definition

ChEBI: A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.

brand name

Lamisil

Clinical Use

(E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene-methanamine hydrochloride (Lamisil) is an off-whitecrystalline material that is soluble in polar organic solventssuch as methanol, ethanol, and methylene chloride but isonly slightly soluble in water. The highly lipophilic freebase is insoluble in water. Terbinafine hydrochloride isavailable in a 1% cream for topical administration for thetreatment of tinea pedis, tinea corporis, and tinea cruris.Terbinafine is more potent than naftifine and has alsodemonstrated oral activity against onychomycosis (ringwormof the nails). It has not been approved in the UnitedStates for oral administration.

Terbinafine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Terbinafine Hydrochloride Suppliers

Global( 427)Suppliers
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Jinan Chenghui-Shuangda Chemical Co.,Ltd
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career henan chemical co
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Hubei XinRunde Chemical Co., Ltd.
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View Lastest Price from Terbinafine Hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-09-17 Terbinafine HCl
78628-80-5
US $120.00-120.00 / KG 1KG 99.0%/EP9 10 tons Jinan Chenghui-Shuangda Chemical Co.,Ltd
2019-04-11 Terbinafine HCl
78628-80-5
US $1.00 / kg 1kg 99% 500KG Hebei Jimi Trading Co., Ltd.
2018-12-14 Terbinafine Hydrochloride
78628-80-5
US $7.00 / kg 1kg 99% 100kg career henan chemical co

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