Ethionamide manufacturers and suppliers

Ethionamide suppliers

Properties

Melting point:: 164 °C

Boiling point:: 167 °C / 1mmHg

Density: 1.1332 (rough estimate)

refractive index: 1.5500 (estimate)

Flash point:: >110°(230°F)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 4.37(H2O t=25.0 I=0.025) (Uncertain)

form: Solid

color: Yellow

Water Solubility: Soluble in DMSO. Sparingly soluble in water

Merck: 14,3737

BCS Class: 3/1

Major Application: pharmaceutical (small molecule)

InChI: 1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

InChIKey: AEOCXXJPGCBFJA-UHFFFAOYSA-N

SMILES: CCc1cc(ccn1)C(N)=S

CAS DataBase Reference: 536-33-4(CAS DataBase Reference)

IARC: 3 (Vol. 13, Sup 7) 1987

NIST Chemistry Reference: Ethionamide(536-33-4)

EPA Substance Registry System: Ethionamide (536-33-4)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H361

Precautionary statements: P280-P301+P312+P330

Hazard Codes: Xn

Risk Statements: 22-63

Safety Statements: 36/37

WGK Germany: 3

RTECS: NS0350000

HS Code: 29333990

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Repr. 2

Hazardous Substances Data: 536-33-4(Hazardous Substances Data)

Toxicity: LD50 oral in rat: 1320mg/kg

Use

2-Ethylthioisonicotinamide (Trecator SC) occurs as a yellowcrystalline material that is sparingly soluble in water. Thisnicotinamide has weak bacteriostatic activity in vitro but, becauseof its lipid solubility, is effective in vivo. In contrast tothe isoniazid series, 2-substitution enhances activity in thethioisonicotinamide series.Ethionamide is rapidly and completely absorbed followingoral administration. It is widely distributed throughoutthe body and extensively metabolized to predominantly inactiveforms that are excreted in the urine. Less than 1% ofthe parent drug appears in the urine.Ethionamide is considered a secondary drug for the treatmentof tuberculosis. It is used in the treatment of isoniazidresistanttuberculosis or when the patient is intolerant toisoniazid and other drugs. Because of its low potency, thehighest tolerated dose of ethionamide is usually recommended.Gastrointestinal intolerance is the most commonside effect associated with its use. Visual disturbances andhepatotoxicity have also been reported.

You can find Ethionamide suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.