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ChemicalBook >> CAS DataBase List >> 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

$5 - $2597
Product name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
CAS: 1124329-14-1
MF: C24H32N6O3
MW: 452.55
EINECS:
MDL Number:MFCD18384959
Synonyms:9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one;AZ 3146;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9;AZ 3146; AZ-3146;CS-511

Price38 Properties Safety Information Description

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AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Ark Pharm
Axon Medchem
Biorbyt Ltd
Biosynth Carbosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
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10mM(in 1mL Ethanol)

ManufacturerAK Scientific
Product numberSYN5485
Product descriptionAZ3146
Packaging100mg
Price$810
Updated2021-12-16
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ManufacturerAK Scientific
Product numberY0290
Product descriptionAZ3146
Packaging1g
Price$2597
Updated2021-12-16
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ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging1mg
Price$5
Updated2021-12-16
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ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging5mg
Price$7
Updated2021-12-16
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ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging10mg
Price$9
Updated2021-12-16
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ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging50mg
Price$15
Updated2021-12-16
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ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging100mg
Price$26
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA174095
Product description9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%
Packaging250mg
Price$48
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000889
Product descriptionAZ-3146 95.00%
Packaging5MG
Price$249.7
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8372
Product descriptionAZ3146
Packaging10mg
Price$85
Updated2021-12-16
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ManufacturerApexBio Technology
Product numberA8372
Product descriptionAZ3146
Packaging10mM(in 1mL Ethanol)
Price$94
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA8372
Product descriptionAZ3146
Packaging50mg
Price$250
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA8372
Product descriptionAZ3146
Packaging100mg
Price$450
Updated2021-12-16
Buy

ManufacturerArk Pharm
Product numberP000532853
Product descriptionAZ3146 98+%
Packaging5mg
Price$95
Updated2021-12-16
Buy

ManufacturerArk Pharm
Product numberP000532853
Product descriptionAZ3146 98+%
Packaging10mg
Price$161
Updated2021-12-16
Buy

ManufacturerArk Pharm
Product numberP000532853
Product descriptionAZ3146 98+%
Packaging50mg
Price$504
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	SYN5485	AZ3146	100mg	$810	2021-12-16	Buy
AK Scientific	Y0290	AZ3146	1g	$2597	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	1mg	$5	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	5mg	$7	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	10mg	$9	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	50mg	$15	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	100mg	$26	2021-12-16	Buy
Ambeed	A174095	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one 98+%	250mg	$48	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000889	AZ-3146 95.00%	5MG	$249.7	2021-12-16	Buy
ApexBio Technology	A8372	AZ3146	10mg	$85	2021-12-16	Buy
ApexBio Technology	A8372	AZ3146	10mM(in 1mL Ethanol)	$94	2021-12-16	Buy
ApexBio Technology	A8372	AZ3146	50mg	$250	2021-12-16	Buy
ApexBio Technology	A8372	AZ3146	100mg	$450	2021-12-16	Buy
Ark Pharm	P000532853	AZ3146 98+%	5mg	$95	2021-12-16	Buy
Ark Pharm	P000532853	AZ3146 98+%	10mg	$161	2021-12-16	Buy
Ark Pharm	P000532853	AZ3146 98+%	50mg	$504	2021-12-16	Buy

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Properties

Boiling point :621.0±65.0 °C(Predicted)
Density :1.279
storage temp. :Store at +4°C
solubility :Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form :solid
pka :8.29±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Properties

Safety Information

Description

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