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ChemicalBook >> CAS DataBase List >> N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine price.
  • $40 - $2250
  • Product name: N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
  • CAS: 1507370-20-8
  • MF: C26H26N4
  • MW: 394.51
  • EINECS:
  • MDL Number:
  • Synonyms:BC-1215;N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine;BC-1215 (BC 1215;1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-;BC-1215 >=98% (HPLC);{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine;N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine;Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF
Price24 Properties Safety Information Description
24 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • Arctom
  • Cayman Chemical
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number0448DW
  • Product descriptionN,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
  • Packaging25mg
  • Price$606
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging5mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging10mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging25mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging50mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging100mg
  • Price$269
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging250mg
  • Price$539
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1173075
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+%
  • Packaging1g
  • Price$1299
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging5mg
  • Price$73
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging10mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging25mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging50mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging100mg
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging250mg
  • Price$534
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS016808
  • Product descriptionN1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98%
  • Packaging1g
  • Price$1286
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21964
  • Product descriptionBC-1215 ≥98%
  • Packaging1mg
  • Price$40
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0448DW N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine 25mg $606 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 5mg $74 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 10mg $112 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 25mg $145 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 50mg $188 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 100mg $269 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 250mg $539 2021-12-16 Buy
Ambeed A1173075 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine 98+% 1g $1299 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 5mg $73 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 10mg $111 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 25mg $144 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 50mg $186 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 100mg $266 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 250mg $534 2021-12-16 Buy
Arctom AS016808 N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine ≥98% 1g $1286 2021-12-16 Buy
Cayman Chemical 21964 BC-1215 ≥98% 1mg $40 2024-03-01 Buy
Next Last

Properties

Boiling point :589.9±50.0 °C(Predicted)
Density :1.125±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :9.05±0.20(Predicted)
form :A crystalline solid
color :white to beige
InChI :InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKey :IXEPQJQQSLMESJ-UHFFFAOYSA-N
SMILES :C(NCC1=CC=C(C2=NC=CC=C2)C=C1)CNCC1=CC=C(C2=NC=CC=C2)C=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine) is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.

Suppliers and manufacturers

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