N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
![N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide price.](/CAS/20200611/GIF/1693731-40-6.gif)
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- $37 - $2520
- Product name: N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
- CAS: 1693731-40-6
- MF: C32H32N4O5
- MW: 552.62
- EINECS:-0
- MDL Number:MFCD30738050
- Synonyms:CCT251236;N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide;CS-2478;CCT251236;CCT-251236;CCT 251236;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-;CCT-251236,CCT251236
12 prices
Selected condition：
Brand
- AK Scientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number2195EF
- Product descriptionN-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide
- Packaging5mg
- Price$266
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2699
- Product descriptionCCT251236 99%
- Packaging5mg
- Price$159.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27788
- Product descriptionCCT251236
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27788
- Product descriptionCCT251236
- Packaging5mg
- Price$151
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27788
- Product descriptionCCT251236
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27788
- Product descriptionCCT251236
- Packaging25mg
- Price$573
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6956
- Product descriptionCCT251236 >99.0%
- Packaging1mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6956
- Product descriptionCCT251236 >99.0%
- Packaging5mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6956
- Product descriptionCCT251236 >99.0%
- Packaging10mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6956
- Product descriptionCCT251236 >99.0%
- Packaging50mg
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6956
- Product descriptionCCT251236 >99.0%
- Packaging100mg
- Price$2520
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10498
- Product descriptionCCT251236 >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2195EF | N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide | 5mg | $266 | 2021-12-16 | Buy |
| Axon Medchem | Axon2699 | CCT251236 99% | 5mg | $159.5 | 2021-12-16 | Buy |
| Cayman Chemical | 27788 | CCT251236 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 27788 | CCT251236 | 5mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 27788 | CCT251236 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 27788 | CCT251236 | 25mg | $573 | 2024-03-01 | Buy |
| ChemScene | CS-6956 | CCT251236 >99.0% | 1mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-6956 | CCT251236 >99.0% | 5mg | $396 | 2021-12-16 | Buy |
| ChemScene | CS-6956 | CCT251236 >99.0% | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-6956 | CCT251236 >99.0% | 50mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-6956 | CCT251236 >99.0% | 100mg | $2520 | 2021-12-16 | Buy |
| DC Chemicals | DC10498 | CCT251236 >98% | 1g | $1800 | 2021-12-16 | Buy |
Properties
Boiling point :628.7±55.0 °C(Predicted)
Density :1.328±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (5 mg/ml)
form :solid
pka :12.18±0.70(Predicted)
color :Off-white/beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Density :1.328±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (5 mg/ml)
form :solid
pka :12.18±0.70(Predicted)
color :Off-white/beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
CCT251236 (1693731-40-6) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2Related product price
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