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ChemicalBook >> CAS DataBase List >> Trametinib

Trametinib

Trametinib price.
  • $55 - $248
  • Product name: Trametinib
  • CAS: 871700-17-3
  • MF: C26H23FIN5O4
  • MW: 615.3947932
  • EINECS:
  • MDL Number:MFCD17215075
  • Synonyms:N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide GSK-1120212;Trametinib free base;Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-;Mekinist trametinib;Trametinib (GSK1120212,JTP 74057);Trametinib, >=98%;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-tri;GSK-1120212
4 prices
Selected condition:

Brand

  • Cayman Chemical

Package

  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerCayman Chemical
  • Product number16292
  • Product descriptionTrametinib ≥95%
  • Packaging25mg
  • Price$55
  • Updated2018-11-19
  • Buy
  • ManufacturerCayman Chemical
  • Product number16292
  • Product descriptionTrametinib ≥95%
  • Packaging50mg
  • Price$94
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number16292
  • Product descriptionTrametinib ≥95%
  • Packaging100mg
  • Price$110
  • Updated2018-11-19
  • Buy
  • ManufacturerCayman Chemical
  • Product number16292
  • Product descriptionTrametinib ≥95%
  • Packaging250mg
  • Price$248
  • Updated2019-12-02
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 16292 Trametinib ≥95% 25mg $55 2018-11-19 Buy
Cayman Chemical 16292 Trametinib ≥95% 50mg $94 2018-11-13 Buy
Cayman Chemical 16292 Trametinib ≥95% 100mg $110 2018-11-19 Buy
Cayman Chemical 16292 Trametinib ≥95% 250mg $248 2019-12-02 Buy

Properties

Melting point: :300-301 °C
Density  :1.74
form  :White solid.
pka :14.76±0.70(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The dual specificity mitogen-activated protein kinase kinases (MEK) isoforms MEK1 and MEK2 function in a RAS/RAF/MEK/ERK signaling pathway to control cell growth, survival, and differentiation. Trametinib is a potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM, respectively). It shows specificity for MEK1/2 over a panel of more than 180 kinases, including B-Raf, c-Raf, and MEK5. Trametinib blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mice. Trametinib, alone or in combination with other chemotherapeutic drugs, targets a subset of cancer cells that can be characterized by specific biomarkers, such as B-Raf, RAS, or CTNNB1 mutations.

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