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ChemicalBook >> CAS DataBase List >> Cabozantinib

Cabozantinib

Cabozantinib price.
  • $7 - $2167
  • Product name: Cabozantinib
  • CAS: 849217-68-1
  • MF: C28H24FN3O5
  • MW: 501.51
  • EINECS:692-846-8
  • MDL Number:MFCD20926324
  • Synonyms:Cabozantinib(XL184Malate);Cabozantinib (XL184, BMS-907351);XL-186;1,1-cyclopropanedicarboxamide, n'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-n-(4-fluorophenyl)-;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide Cabozantinib (XL184, BMS-907351);Cabozantinib, >=98%;1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Cabozantinib
Price41 Properties Safety Information Description
41 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
Package
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  • 1mg
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  • 10g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-C0755-M010
  • Product descriptionCabozantinib ≥98%(HPLC)
  • Packaging10mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1138-M050
  • Product descriptionCabozantinib ≥95%
  • Packaging50mg
  • Price$497
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1138
  • Product descriptionCabozantinib
  • Packaging10mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1138
  • Product descriptionCabozantinib
  • Packaging100mg
  • Price$845
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging10mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging50mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging100mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging250mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging1g
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging10g
  • Price$381
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA200488
  • Product descriptionN-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+%
  • Packaging5g
  • Price$381
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging10MG
  • Price$716.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging50MG
  • Price$1120.35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0028641
  • Product descriptionCABOZANTINIB 95.00%
  • Packaging200MG
  • Price$2167
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA2977
  • Product descriptionCabozantinib(XL184,BMS-907351)
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-C0755-M010 Cabozantinib ≥98%(HPLC) 10mg $129 2021-12-16 Buy
Adipogen Life Sciences SYN-1138-M050 Cabozantinib ≥95% 50mg $497 2021-12-16 Buy
AK Scientific SYN1138 Cabozantinib 10mg $190 2021-12-16 Buy
AK Scientific SYN1138 Cabozantinib 100mg $845 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 10mg $7 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 5mg $7 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 50mg $12 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 100mg $15 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 250mg $65 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 1g $212 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 10g $381 2021-12-16 Buy
Ambeed A200488 N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 98+% 5g $381 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 10MG $716.1 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 50MG $1120.35 2021-12-16 Buy
American Custom Chemicals Corporation API0028641 CABOZANTINIB 95.00% 200MG $2167 2021-12-16 Buy
ApexBio Technology A2977 Cabozantinib(XL184,BMS-907351) 5mg $70 2021-12-16 Buy
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Properties

Melting point :212-215°C
Boiling point :758.1±60.0 °C(Predicted)
Density :1.396
storage temp. :-20°C
solubility :Soluble in DMSO
form :White powder.
pka :13.86±0.70(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :ONIQOQHATWINJY-UHFFFAOYSA-N
SMILES :C1(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C=C2)=O)(C(NC2=CC=C(F)C=C2)=O)CC1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

XL184 is a pan tyrosine kinase inhibitor that primarily targets VEGFR2 (IC50 = 0.035 nM) and c-Met (IC50 = 1.3 nM) but also inhibits RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively). In in vivo breast, lung, and glioma tumor models that represent dysregulated c-Met and VEGFR signaling, XL184 was shown to reduce tumor and endothelial cell proliferation, inhibiting both angiogenesis and metastasis. XL184 has undergone clinical trial in a broad number of cancers, including thyroid carcinoma, prostate cancer, ovarian cancer, melanoma, breast cancer, non-small cell lung cancer, hepatocellular cancer, renal cell carcinoma, and glioblastoma.

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Suppliers and manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
$0.00 /25kg
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide CAS:849217-68-1
shandong perfect biotechnology co.ltd
Cabozantinib
$0.00 /1g
Cabozantinib CAS:849217-68-1
Jewim Pharmaceutical (Shandong) Co., Ltd.
Jinan Good Medical Technology Co.,Ltd
Capot Chemical Co.,Ltd.
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.