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ChemicalBook >> CAS DataBase List >> A 419259 trihydrochloride

A 419259 trihydrochloride

A 419259 trihydrochloride price.
  • $35 - $894
  • Product name: A 419259 trihydrochloride
  • CAS: 364042-47-7
  • MF: C29H34N6O
  • MW: 482.62
  • EINECS:
  • MDL Number:MFCD28155266
  • Synonyms:A 419259;A419259;A-419259;RK 20449;RK20449;RK-20449;7-[Trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride;A 419259 trihydrochloride
11 prices
Selected condition:
Brand
  • Cayman Chemical
  • Crysdot
  • CSNpharm
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 10
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerCayman Chemical
  • Product number25605
  • Product descriptionA-419259 ≥98%
  • Packaging500μg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25605
  • Product descriptionA-419259 ≥98%
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25605
  • Product descriptionA-419259 ≥98%
  • Packaging5mg
  • Price$199
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25605
  • Product descriptionA-419259 ≥98%
  • Packaging10mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002088
  • Product descriptionA419259 98+%
  • Packaging10mg
  • Price$127
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002088
  • Product descriptionA419259 98+%
  • Packaging50mg
  • Price$441
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN18243
  • Product descriptionA419259
  • Packaging10mg
  • Price$184
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0446
  • Product descriptionA-419259 trihydrochloride ≥98% (HPLC)
  • Packaging5mg
  • Price$213
  • Updated2025-07-31
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0446
  • Product descriptionA-419259 trihydrochloride ≥98% (HPLC)
  • Packaging25mg
  • Price$894
  • Updated2025-07-31
  • Buy
  • ManufacturerTocris
  • Product number3914
  • Product descriptionA-419259 trihydrochloride ≥98%(HPLC)
  • Packaging10
  • Price$331
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number254469
  • Product descriptionA 419259 trihydrochloride
  • Packaging10mg
  • Price$588
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 25605 A-419259 ≥98% 500μg $35 2021-12-16 Buy
Cayman Chemical 25605 A-419259 ≥98% 1mg $81 2024-03-01 Buy
Cayman Chemical 25605 A-419259 ≥98% 5mg $199 2024-03-01 Buy
Cayman Chemical 25605 A-419259 ≥98% 10mg $356 2024-03-01 Buy
Crysdot CD31002088 A419259 98+% 10mg $127 2021-12-16 Buy
Crysdot CD31002088 A419259 98+% 50mg $441 2021-12-16 Buy
CSNpharm CSN18243 A419259 10mg $184 2021-12-16 Buy
Sigma-Aldrich SML0446 A-419259 trihydrochloride ≥98% (HPLC) 5mg $213 2025-07-31 Buy
Sigma-Aldrich SML0446 A-419259 trihydrochloride ≥98% (HPLC) 25mg $894 2025-07-31 Buy
Tocris 3914 A-419259 trihydrochloride ≥98%(HPLC) 10 $331 2021-12-16 Buy
Usbiological 254469 A 419259 trihydrochloride 10mg $588 2021-12-16 Buy

Properties

Boiling point :686.4±55.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :H2O: soluble10mg/mL (clear solution)
pka :8.20±0.42(Predicted)
form :powder
color :white to beige
Water Solubility :H2O: 10mg/mL (clear solution)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC50s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC50 = 3,000 nM) and PKC (IC50 = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph+) K-562 and Meg-01 myeloid leukemia cells (IC50s = 0.1-0.3 and 0.1 μM, respectively), but not Ph- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.