AT9283
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- $70 - $4365.9
- Product name: AT9283
- CAS: 896466-04-9
- MF: C19H23N7O2
- MW: 381.43
- EINECS:
- MDL Number:MFCD12031513
- Synonyms:1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283;AT9283, >=98%;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;CS-48;AT-9283; AT 9283;J-504568
45 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 10mM(in 1mL DMSO)
- 2mg
- 2x5mg
- 1mg
- 5mg
- 10mM(in1mLDMSO)
- 10mg
- 25mg
- 2x25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1011-M001
- Product descriptionAT9283 ≥95%
- Packaging1mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1011-M001
- Product descriptionAT9283 ≥95%
- Packaging1mg
- Price$86
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1011-M005
- Product descriptionAT9283 ≥95%
- Packaging5mg
- Price$162
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1011-M010
- Product descriptionAT9283 ≥95%
- Packaging10mg
- Price$270
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1011-M050
- Product descriptionAT9283 ≥95%
- Packaging50mg
- Price$799
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberX7478
- Product description1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
- Packaging250mg
- Price$1887
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7478
- Product description1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
- Packaging1g
- Price$4132
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000410
- Product descriptionAT-9283 95.00%
- Packaging1G
- Price$4365.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging100mg
- Price$770
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging100mg
- Price$770
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging50mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging50mg
- Price$470
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging10mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging5mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4117
- Product descriptionAT9283
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1011-M001 | AT9283 ≥95% | 1mg | $86 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1011-M001 | AT9283 ≥95% | 1mg | $86 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1011-M005 | AT9283 ≥95% | 5mg | $162 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1011-M010 | AT9283 ≥95% | 10mg | $270 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1011-M050 | AT9283 ≥95% | 50mg | $799 | 2026-05-06 | Buy |
| AK Scientific | X7478 | 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea | 250mg | $1887 | 2021-12-16 | Buy |
| AK Scientific | X7478 | 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea | 1g | $4132 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000410 | AT-9283 95.00% | 1G | $4365.9 | 2021-12-16 | Buy |
| ApexBio Technology | A4117 | AT9283 | 100mg | $770 | 2021-12-16 | Buy |
| ApexBio Technology | A4117 | AT9283 | 100mg | $770 | 2026-05-06 | Buy |
| ApexBio Technology | A4117 | AT9283 | 50mg | $470 | 2021-12-16 | Buy |
| ApexBio Technology | A4117 | AT9283 | 50mg | $470 | 2026-05-06 | Buy |
| ApexBio Technology | A4117 | AT9283 | 10mg | $160 | 2026-05-06 | Buy |
| ApexBio Technology | A4117 | AT9283 | 5mg | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A4117 | AT9283 | 5mg | $90 | 2026-05-06 | Buy |
| ApexBio Technology | A4117 | AT9283 | 10mg | $160 | 2021-12-16 | Buy |
Properties
Density :1.45
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :solid
pka :10.58±0.10(Predicted)
color :White to off-white
InChIKey :LOLPPWBBNUVNQZ-UHFFFAOYSA-N
SMILES :[nH]1nc(c(c1)NC(=O)NC5CC5)c2[nH]c3c(n2)ccc(c3)CN4CCOCC4
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form :solid
pka :10.58±0.10(Predicted)
color :White to off-white
InChIKey :LOLPPWBBNUVNQZ-UHFFFAOYSA-N
SMILES :[nH]1nc(c(c1)NC(=O)NC5CC5)c2[nH]c3c(n2)ccc(c3)CN4CCOCC4
Safety Information
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Description
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.Related product price
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