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ChemicalBook >> CAS DataBase List >> Bisindolylmaleimide II

Bisindolylmaleimide II

Bisindolylmaleimide II price.
  • $55 - $1290
  • Product name: Bisindolylmaleimide II
  • CAS: 137592-45-1
  • MF: C27H26N4O2
  • MW: 438.52
  • EINECS:
  • MDL Number:MFCD00236430
  • Synonyms:3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione;2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE;3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-;Bisindolylmaleimide II, PKC inhibitor;(rac)-AR-13503;Bisindolylmaleimide II
Price21 Properties Safety Information Description
21 prices
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Brand
  • aablocks
  • Adipogen Life Sciences
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • CSNpharm
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 5mg
  • 10
  • 10mg
  • 50mg
  • 1 mg
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
  • Packaging1mg
  • Price$107
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBisindolylmaleimide II >98%
  • Packaging5mg
  • Price$213
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBisindolylmaleimide II >98%
  • Packaging10mg
  • Price$324
  • Updated2026-05-28
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M001
  • Product descriptionBisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR)
  • Packaging1mg
  • Price$55
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M005
  • Product descriptionBisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR)
  • Packaging5mg
  • Price$165
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimide II
  • Packaging10mg
  • Price$314
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimide II
  • Packaging50mg
  • Price$1290
  • Updated2026-05-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97%(isomermixture)
  • Packaging5mg
  • Price$190
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97%(isomermixture)
  • Packaging1mg
  • Price$63
  • Updated2026-04-30
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0029291
  • Product descriptionBisindolylmaleimide II 99.80%
  • Packaging5mg
  • Price$173
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0029291
  • Product descriptionBisindolylmaleimide II 99.80%
  • Packaging10mg
  • Price$282
  • Updated2026-06-04
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22715
  • Product descriptionBisindolylmaleimideII
  • Packaging50mg
  • Price$655
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN22715
  • Product descriptionBisindolylmaleimideII
  • Packaging5mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB3056
  • Product descriptionBisindolylmaleimide II ≥97% (Mixture of 2 isomers)
  • Packaging1 mg
  • Price$154
  • Updated2026-04-30
  • Buy
  • ManufacturerTocris
  • Product number4128
  • Product descriptionBisindolylmaleimideII ≥97%(HPLC)
  • Packaging50
  • Price$887
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4128
  • Product descriptionBisindolylmaleimideII ≥97%(HPLC)
  • Packaging10
  • Price$216
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009AQ2 BISINDOLYLMALEIMIDEII ≥97%(isomermixture) 1mg $107 2021-12-16 Buy
aablocks AA009AQ2 Bisindolylmaleimide II >98% 5mg $213 2026-05-28 Buy
aablocks AA009AQ2 Bisindolylmaleimide II >98% 10mg $324 2026-05-28 Buy
Adipogen Life Sciences AG-CR1-0010-M001 Bisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR) 1mg $55 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-0010-M005 Bisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR) 5mg $165 2026-05-06 Buy
ApexBio Technology B7595 Bisindolylmaleimide II 10mg $314 2026-05-06 Buy
ApexBio Technology B7595 Bisindolylmaleimide II 50mg $1290 2026-05-06 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97%(isomermixture) 5mg $190 2026-04-30 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97%(isomermixture) 1mg $63 2026-04-30 Buy
ChemScene CS-0029291 Bisindolylmaleimide II 99.80% 5mg $173 2026-06-04 Buy
ChemScene CS-0029291 Bisindolylmaleimide II 99.80% 10mg $282 2026-06-04 Buy
CSNpharm CSN22715 BisindolylmaleimideII 50mg $655 2021-12-16 Buy
CSNpharm CSN22715 BisindolylmaleimideII 5mg $112 2021-12-16 Buy
Sigma-Aldrich B3056 Bisindolylmaleimide II ≥97% (Mixture of 2 isomers) 1 mg $154 2026-04-30 Buy
Tocris 4128 BisindolylmaleimideII ≥97%(HPLC) 50 $887 2021-12-16 Buy
Tocris 4128 BisindolylmaleimideII ≥97%(HPLC) 10 $216 2021-12-16 Buy
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Properties

Boiling point :709.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
color :Yellow to orange
biological source :synthetic (organic)
InChIKey :LBFDERUQORUFIN-UHFFFAOYSA-N
SMILES :CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 μM, BIM II inhibits 98% of PKCα kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.

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Suppliers and manufacturers

3B Pharmachem (Wuhan) International Co.,Ltd. EMMX Biotechnology LLC Shanghai EFE Biological Technology Co., Ltd. BOC Sciences TargetMol Chemicals Inc. ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc. Nantong QuanYi Biotechnology Co., Ltd RD International Technology Co., Limited