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ChemicalBook >> CAS DataBase List >> BISINDOLYLMALEIMIDE II

BISINDOLYLMALEIMIDE II

BISINDOLYLMALEIMIDE II price.
  • $55 - $1290
  • Product name: BISINDOLYLMALEIMIDE II
  • CAS: 137592-45-1
  • MF: C27H26N4O2
  • MW: 438.52
  • EINECS:
  • MDL Number:MFCD00236430
  • Synonyms:BISINDOLYLMALEIMIDE II;3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione;2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE;3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-;Bisindolylmaleimide II, PKC inhibitor
Price25 Properties Safety Information Description
25 prices
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Brand
  • aablocks
  • Adipogen Life Sciences
  • ApexBio Technology
  • Cayman Chemical
  • CSNpharm
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 5mg
  • 10
  • 10mg
  • 50mg
  • 1 mg
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
  • Packaging1mg
  • Price$107
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBisindolylmaleimide II >98%
  • Packaging5mg
  • Price$213
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
  • Packaging5mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009AQ2
  • Product descriptionBisindolylmaleimide II >98%
  • Packaging10mg
  • Price$324
  • Updated2026-05-28
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M001
  • Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
  • Packaging1mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M001
  • Product descriptionBisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR)
  • Packaging1mg
  • Price$55
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M005
  • Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
  • Packaging5mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0010-M005
  • Product descriptionBisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR)
  • Packaging5mg
  • Price$165
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimideII
  • Packaging10mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimide II
  • Packaging10mg
  • Price$314
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimideII
  • Packaging50mg
  • Price$1290
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7595
  • Product descriptionBisindolylmaleimide II
  • Packaging50mg
  • Price$1290
  • Updated2026-05-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
  • Packaging5mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97%(isomermixture)
  • Packaging5mg
  • Price$190
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11020
  • Product descriptionBisindolylmaleimide II ≥97%(isomermixture)
  • Packaging1mg
  • Price$63
  • Updated2026-04-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009AQ2 BISINDOLYLMALEIMIDEII ≥97%(isomermixture) 1mg $107 2021-12-16 Buy
aablocks AA009AQ2 Bisindolylmaleimide II >98% 5mg $213 2026-05-28 Buy
aablocks AA009AQ2 BISINDOLYLMALEIMIDEII ≥97%(isomermixture) 5mg $225 2021-12-16 Buy
aablocks AA009AQ2 Bisindolylmaleimide II >98% 10mg $324 2026-05-28 Buy
Adipogen Life Sciences AG-CR1-0010-M001 BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) 1mg $55 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-0010-M001 Bisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR) 1mg $55 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-0010-M005 BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) 5mg $165 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-0010-M005 Bisindolylmaleimide II ≥97%(mixtureof2isomers)(NMR) 5mg $165 2026-05-06 Buy
ApexBio Technology B7595 BisindolylmaleimideII 10mg $314 2021-12-16 Buy
ApexBio Technology B7595 Bisindolylmaleimide II 10mg $314 2026-05-06 Buy
ApexBio Technology B7595 BisindolylmaleimideII 50mg $1290 2021-12-16 Buy
ApexBio Technology B7595 Bisindolylmaleimide II 50mg $1290 2026-05-06 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97% (isomer mixture) 5mg $172 2024-03-01 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97%(isomermixture) 5mg $190 2026-04-30 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97% (isomer mixture) 1mg $57 2024-03-01 Buy
Cayman Chemical 11020 Bisindolylmaleimide II ≥97%(isomermixture) 1mg $63 2026-04-30 Buy
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Properties

Boiling point :709.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
color :Yellow to orange
biological source :synthetic (organic)
InChIKey :LBFDERUQORUFIN-UHFFFAOYSA-N
SMILES :CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 μM, BIM II inhibits 98% of PKCα kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
BOC Sciences
Aladdin Scientific 3B Pharmachem (Wuhan) International Co.,Ltd. EMMX Biotechnology LLC Shanghai EFE Biological Technology Co., Ltd. BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc.