BISINDOLYLMALEIMIDE II
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- $55 - $1290
- Product name: BISINDOLYLMALEIMIDE II
- CAS: 137592-45-1
- MF: C27H26N4O2
- MW: 438.52
- EINECS:
- MDL Number:MFCD00236430
- Synonyms:BISINDOLYLMALEIMIDE II;3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione;2-[1-[2-(1-METHYLPYRROLIDINO)ETHYL]-1H-INDOL-3-YL]-3-(1H-INDOL-3-YL)MALEIMIDE;3-(1H-indol-3-yl)-4-[1-[2-(1-methylpyrrolidin-2-yl)ethyl]indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-
14 prices
Selected condition：
Brand
- aablocks
- Adipogen Life Sciences
- ApexBio Technology
- Cayman Chemical
- CSNpharm
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 50
- 5mg
- 10mg
- 50mg
- Manufactureraablocks
- Product numberAA009AQ2
- Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
- Packaging1mg
- Price$107
- Updated2021-12-16
- Buy
- Manufactureraablocks
- Product numberAA009AQ2
- Product descriptionBISINDOLYLMALEIMIDEII ≥97%(isomermixture)
- Packaging5mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0010-M001
- Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
- Packaging1mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0010-M005
- Product descriptionBisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR)
- Packaging5mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7595
- Product descriptionBisindolylmaleimideII
- Packaging10mg
- Price$314
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7595
- Product descriptionBisindolylmaleimideII
- Packaging50mg
- Price$1290
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11020
- Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11020
- Product descriptionBisindolylmaleimide II ≥97% (isomer mixture)
- Packaging5mg
- Price$172
- Updated2024-03-01
- Buy
- ManufacturerCSNpharm
- Product numberCSN22715
- Product descriptionBisindolylmaleimideII
- Packaging5mg
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22715
- Product descriptionBisindolylmaleimideII
- Packaging50mg
- Price$655
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4128
- Product descriptionBisindolylmaleimideII ≥97%(HPLC)
- Packaging10
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4128
- Product descriptionBisindolylmaleimideII ≥97%(HPLC)
- Packaging50
- Price$887
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberB448535
- Product descriptionBisindolylmaleimideII
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number044603
- Product descriptionBisindolylmaleimide II
- Packaging1mg
- Price$295
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009AQ2 | BISINDOLYLMALEIMIDEII ≥97%(isomermixture) | 1mg | $107 | 2021-12-16 | Buy |
| aablocks | AA009AQ2 | BISINDOLYLMALEIMIDEII ≥97%(isomermixture) | 5mg | $225 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0010-M001 | BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) | 1mg | $55 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0010-M005 | BisindolylmaleimideII ≥97%(mixtureof2isomers)(NMR) | 5mg | $165 | 2021-12-16 | Buy |
| ApexBio Technology | B7595 | BisindolylmaleimideII | 10mg | $314 | 2021-12-16 | Buy |
| ApexBio Technology | B7595 | BisindolylmaleimideII | 50mg | $1290 | 2021-12-16 | Buy |
| Cayman Chemical | 11020 | Bisindolylmaleimide II ≥97% (isomer mixture) | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 11020 | Bisindolylmaleimide II ≥97% (isomer mixture) | 5mg | $172 | 2024-03-01 | Buy |
| CSNpharm | CSN22715 | BisindolylmaleimideII | 5mg | $112 | 2021-12-16 | Buy |
| CSNpharm | CSN22715 | BisindolylmaleimideII | 50mg | $655 | 2021-12-16 | Buy |
| Tocris | 4128 | BisindolylmaleimideII ≥97%(HPLC) | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 4128 | BisindolylmaleimideII ≥97%(HPLC) | 50 | $887 | 2021-12-16 | Buy |
| TRC | B448535 | BisindolylmaleimideII | 10mg | $150 | 2021-12-16 | Buy |
| Usbiological | 044603 | Bisindolylmaleimide II | 1mg | $295 | 2021-12-16 | Buy |
Properties
Boiling point :709.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: soluble
form :solid
pka :8.17±0.60(Predicted)
Safety Information
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Description
Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine. At 10 μM, BIM II inhibits 98% of PKCα kinase activity. Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM). Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.Related product price
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