CAY10576
|
- $45 - $2806
- Product name: CAY10576
- CAS: 862812-98-4
- MF: C22H19N3O5S2
- MW: 469.53
- EINECS:
- MDL Number:MFCD10567700
- Synonyms:CAY10576;IKK-3 Inhibitor;2-Thiophenecarbonitrile, 5-(5,6-diMethoxy-1H-benziMidazol-1-yl)-3-[[2-(Methylsulfonyl)phenyl]Methoxy]-;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile;5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile;GSK-319347A,GSK319347A;IKK-epsilon Kinase Inhibitor II, Inhibitor of IkappaB kinases (IKK);GSK319347A, 10 mM in DMSO
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10mg
- 25MG
- 50mg
- 100MG
- Manufactureraablocks
- Product numberAA004JE6
- Product descriptionCAY10576 ≥95%
- Packaging1mg
- Price$50
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004JE6
- Product descriptionCAY10576 ≥95%
- Packaging10mg
- Price$347
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004JE6
- Product descriptionCAY10576 ≥95%
- Packaging50mg
- Price$1238
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD251409
- Product descriptionGSK319347A 98%
- Packaging25MG
- Price$535
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD251409
- Product descriptionGSK319347A 98%
- Packaging10MG
- Price$295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD251409
- Product descriptionGSK319347A 98%
- Packaging100MG
- Price$1605
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number1798AH
- Product descriptionIKK-3Inhibitor
- Packaging5mg
- Price$318
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1798AH
- Product descriptionIKK-3Inhibitor
- Packaging10mg
- Price$488
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0150862
- Product description5-(5,6-DIMETHOXY-1H-BENZIMIDAZOL-1-YL)-3-((2-(METHYLSULFONYL)PHENYL)METHOXY)-2-THIOPHENECARBONITRILE 95.00%
- Packaging5MG
- Price$500.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3486
- Product descriptionIKK-3 Inhibitor
- Packaging5mg
- Price$374
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3486
- Product descriptionIKK-3Inhibitor
- Packaging5mg
- Price$914
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3486
- Product descriptionIKK-3Inhibitor
- Packaging1mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3486
- Product descriptionIKK-3 Inhibitor
- Packaging1mg
- Price$123
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-14682
- Product descriptionGSK319347A 99.25%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$177
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14682
- Product descriptionGSK319347A 99.25%
- Packaging5mg
- Price$181
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14682
- Product descriptionGSK319347A 99.25%
- Packaging10mM*1mLinDMSO(Solution)
- Price$187
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA004JE6 | CAY10576 ≥95% | 1mg | $50 | 2026-05-28 | Buy |
| aablocks | AA004JE6 | CAY10576 ≥95% | 10mg | $347 | 2026-05-28 | Buy |
| aablocks | AA004JE6 | CAY10576 ≥95% | 50mg | $1238 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD251409 | GSK319347A 98% | 25MG | $535 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD251409 | GSK319347A 98% | 10MG | $295 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD251409 | GSK319347A 98% | 100MG | $1605 | 2026-05-27 | Buy |
| AK Scientific | 1798AH | IKK-3Inhibitor | 5mg | $318 | 2021-12-16 | Buy |
| AK Scientific | 1798AH | IKK-3Inhibitor | 10mg | $488 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0150862 | 5-(5,6-DIMETHOXY-1H-BENZIMIDAZOL-1-YL)-3-((2-(METHYLSULFONYL)PHENYL)METHOXY)-2-THIOPHENECARBONITRILE 95.00% | 5MG | $500.05 | 2021-12-16 | Buy |
| ApexBio Technology | A3486 | IKK-3 Inhibitor | 5mg | $374 | 2026-05-06 | Buy |
| ApexBio Technology | A3486 | IKK-3Inhibitor | 5mg | $914 | 2021-12-16 | Buy |
| ApexBio Technology | A3486 | IKK-3Inhibitor | 1mg | $299 | 2021-12-16 | Buy |
| ApexBio Technology | A3486 | IKK-3 Inhibitor | 1mg | $123 | 2026-05-06 | Buy |
| Arctom | HY-14682 | GSK319347A 99.25% | 10mM*1mLinDMSO(Solid+Solvent) | $177 | 2026-05-26 | Buy |
| Arctom | HY-14682 | GSK319347A 99.25% | 5mg | $181 | 2026-05-26 | Buy |
| Arctom | HY-14682 | GSK319347A 99.25% | 10mM*1mLinDMSO(Solution) | $187 | 2026-05-26 | Buy |
Properties
Boiling point :744.4±70.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 45 mg/mL (95.84 mM; Need ultrasonic)
form :Powder
pka :3.09±0.10(Predicted)
color :Light yellow to yellow
InChI :1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
InChIKey :LDTAHRLHGHFHKP-UHFFFAOYSA-N
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 45 mg/mL (95.84 mM; Need ultrasonic)
form :Powder
pka :3.09±0.10(Predicted)
color :Light yellow to yellow
InChI :1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
InChIKey :LDTAHRLHGHFHKP-UHFFFAOYSA-N
Safety Information
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Description
CAY10576 is a thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 μM) 1A2, 2D6, 2C9, and 3A4.More related product prices
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CAY10576
$45-2806
