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ChemicalBook >> CAS DataBase List >> CPI-455

CPI-455

CPI-455 price.
  • $9 - $2008
  • Product name: CPI-455
  • CAS: 1628208-23-0
  • MF: C16H14N4O
  • MW: 278.31
  • EINECS:-0
  • MDL Number:MFCD29921343
  • Synonyms:CPI-455;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;CPI 455;CPI455;CPI 455;CPI-455;CPI455;CPI-455, >98%;CPI-455(free base);Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6-(1-methylethyl)-7-oxo-5-phenyl-;CPI 455,Histone Demethylase,CPI455,CPI-455,Inhibitor,inhibit
Price49 Properties Safety Information Description
49 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • AvaChem
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Synthonix
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 2x25mg
  • 50mg
  • 100.00mg
  • 100mg
  • 250.00mg
  • 250mg
  • 1g
  • 1.00g
  • 5g
  • 10g
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging1mg
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98%
  • Packaging5mg
  • Price$11
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging10mg
  • Price$20
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98%
  • Packaging25mg
  • Price$25
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging100mg
  • Price$56
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98%
  • Packaging250mg
  • Price$107
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging1g
  • Price$396
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging5g
  • Price$1342
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00AS2B
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95%
  • Packaging10g
  • Price$2008
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging1G
  • Price$395
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging25MG
  • Price$30
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33798
  • Product descriptionCPI-455 98%
  • Packaging100MG
  • Price$70
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number1814DY
  • Product description6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile
  • Packaging5mg
  • Price$289
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging25mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7811
  • Product description6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number6230
  • Product descriptionCPI-455 98%
  • Packaging5mg
  • Price$90
  • Updated2026-05-22
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 1mg $9 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98% 5mg $11 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 10mg $20 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile ≥98% 25mg $25 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 100mg $56 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 98% 250mg $107 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 1g $396 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 5g $1342 2026-05-28 Buy
aablocks AA00AS2B 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95% 10g $2008 2026-05-28 Buy
ACHEMBLOCK O33798 CPI-455 98% 1G $395 2026-05-27 Buy
ACHEMBLOCK O33798 CPI-455 98% 25MG $30 2026-05-27 Buy
ACHEMBLOCK O33798 CPI-455 98% 100MG $70 2026-05-27 Buy
AK Scientific 1814DY 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 5mg $289 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 25mg $320 2021-12-16 Buy
ApexBio Technology B7811 6-isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride 5mg $85 2021-12-16 Buy
AvaChem 6230 CPI-455 98% 5mg $90 2026-05-22 Buy
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Properties

Boiling point :488.7±55.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :solid
pka :-5.10±0.60(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.

Description

CPI-455 (1628208-23-0) is a potent (IC50= 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2’-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cellsin vitro.2KDM5 demethylases have recently been shown to repress the immune response to tumorsviasuppression of STING.3

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Suppliers and manufacturers

career henan chemical co
CPI-455
$1.00
CPI-455 CAS:1628208-23-0
TargetMol Chemicals Inc.
CPI-455
$31.00
CPI-455 CAS:1628208-23-0
ATK CHEMICAL COMPANY LIMITED
Biochempartner
HANGZHOU CLAP TECHNOLOGY CO.,LTD
BOC Sciences
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd