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ChemicalBook >> CAS DataBase List >> CYCLOTHIAZIDE

CYCLOTHIAZIDE

CYCLOTHIAZIDE price.
  • $44 - $496
  • Product name: CYCLOTHIAZIDE
  • CAS: 2259-96-3
  • MF: C14H16ClN3O4S2
  • MW: 389.88
  • EINECS:218-859-7
  • MDL Number:MFCD00210192
  • Synonyms:7-sulfonamide1,1-dioxide ;Anhydron;Aquirel;Doburil;Fluidil;Lilly 35483;lilly35,483 ;MDi 193
28 prices
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  • aablocks
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
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  • 1mg
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  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • Manufactureraablocks
  • Product numberAA00IMCF
  • Product descriptionCyclothiazide ≥95%
  • Packaging10mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00IMCF
  • Product descriptionCyclothiazide ≥95%
  • Packaging25mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00IMCF
  • Product descriptionCyclothiazide ≥95%
  • Packaging50mg
  • Price$248
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00IMCF
  • Product descriptionCyclothiazide ≥95%
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0091BA
  • Product descriptionCyclothiazide
  • Packaging25mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6415
  • Product descriptionCyclothiazide
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20758
  • Product descriptionCyclothiazide
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20758
  • Product descriptionCyclothiazide
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20758
  • Product descriptionCyclothiazide
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20758
  • Product descriptionCyclothiazide
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC20758
  • Product descriptionCyclothiazide
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16335
  • Product descriptionCyclothiazide ≥95%
  • Packaging10mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16335
  • Product descriptionCyclothiazide ≥95%
  • Packaging25mg
  • Price$104
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16335
  • Product descriptionCyclothiazide ≥95%
  • Packaging50mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16335
  • Product descriptionCyclothiazide ≥95%
  • Packaging100mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number37753
  • Product descriptionCyclothiazide(mixtureofisomers),95%(HPLC) 95%(HPLC)
  • Packaging25MG
  • Price$140
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00IMCF Cyclothiazide ≥95% 10mg $94 2021-12-16 Buy
aablocks AA00IMCF Cyclothiazide ≥95% 25mg $125 2021-12-16 Buy
aablocks AA00IMCF Cyclothiazide ≥95% 50mg $248 2021-12-16 Buy
aablocks AA00IMCF Cyclothiazide ≥95% 100mg $400 2021-12-16 Buy
AK Scientific 0091BA Cyclothiazide 25mg $212 2021-12-16 Buy
ApexBio Technology B6415 Cyclothiazide 10mg $125 2021-12-16 Buy
Biosynth Carbosynth FC20758 Cyclothiazide 5mg $65 2021-12-16 Buy
Biosynth Carbosynth FC20758 Cyclothiazide 10mg $100 2021-12-16 Buy
Biosynth Carbosynth FC20758 Cyclothiazide 25mg $150 2021-12-16 Buy
Biosynth Carbosynth FC20758 Cyclothiazide 50mg $250 2021-12-16 Buy
Biosynth Carbosynth FC20758 Cyclothiazide 100mg $400 2021-12-16 Buy
Cayman Chemical 16335 Cyclothiazide ≥95% 10mg $44 2024-03-01 Buy
Cayman Chemical 16335 Cyclothiazide ≥95% 25mg $104 2024-03-01 Buy
Cayman Chemical 16335 Cyclothiazide ≥95% 50mg $193 2024-03-01 Buy
Cayman Chemical 16335 Cyclothiazide ≥95% 100mg $341 2024-03-01 Buy
Chem-Impex 37753 Cyclothiazide(mixtureofisomers),95%(HPLC) 95%(HPLC) 25MG $140 2021-12-16 Buy

Properties

Melting point :234°
Density :1.3781 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
pka :pKa 9.1(30% EtOH) (Uncertain)
form :White to off-white solid.
color :Off-white
λmax :273nm(lit.)
Merck :14,2754
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
EPA Substance Registry System :2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function. Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 μM). It blocks the rapid agonist-induced desensitization of AMPA receptors, resulting in enhanced excitatory activity. Cyclothiazide is also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 μM).

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