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CYCLOTHIAZIDE

CYCLOTHIAZIDE
CYCLOTHIAZIDE structure
CAS No.
2259-96-3
Chemical Name:
CYCLOTHIAZIDE
Synonyms
Lil;35483;mdi193;Aquador;Aquirel;Doburil;Fluidil;MDi 193;Valmiran;Renazide
CBNumber:
CB6123851
Molecular Formula:
C14H16ClN3O4S2
Formula Weight:
389.88
MOL File:
2259-96-3.mol

CYCLOTHIAZIDE Properties

Melting point:
234°
Density 
1.3781 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
2-8°C
form 
White to off-white solid.
pka
pKa 9.1(30% EtOH) (Uncertain)
λmax
273nm(lit.)
Merck 
14,2754
FDA UNII
P71U09G5BW
EPA Substance Registry System
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  2
RTECS  DK9610000
HS Code  2935904000
Toxicity LD50 oral in rat: > 5gm/kg

CYCLOTHIAZIDE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9847 Cyclothiazide 2259-96-3 10mg $103 2021-03-22 Buy
Sigma-Aldrich 1159008 Cyclothiazide United States Pharmacopeia (USP) Reference Standard 2259-96-3 200mg $350 2021-03-22 Buy
TCI Chemical C3392 Cyclothiazide (mixture of isomers) >95.0%(HPLC) 2259-96-3 25mg $138 2021-03-22 Buy
TCI Chemical C3392 Cyclothiazide (mixture of isomers) >95.0%(HPLC) 2259-96-3 100mg $410 2021-03-22 Buy
Cayman Chemical 16335 Cyclothiazide ≥95% 2259-96-3 10mg $35 2021-03-22 Buy

CYCLOTHIAZIDE Chemical Properties,Uses,Production

Originator

Anhydron,Lilly,US,1963

Uses

Diuretic; antihypertensive. A subunit-specific inhibitor of GABAC receptors

Definition

ChEBI: 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension a d oedema.

Manufacturing Process

A mixture of 8.5 g (0.03 mol) of 6-chloro-4-amino-benzene-1,3- disulfonamide, 4.0 g (0.033 mol) of 2,5-endomethylene-δ3- tetrahydrobenzaldehyde and 25 cc of diethyleneglycol-dimethyl ether was heated for 2 hours at 100°C. During this time the major portion of the initially undissolved crystals went into solution; thereafter, the reaction mixture was allowed to stand for 14 hours at room temperature, during which the remaining undissolved crystals also went into solution. The reddish, clear solution thus obtained was admixed with 50 cc of chloroform. The greyishwhite precipitate formed thereby was separated by vacuum filtration, washed with a small amount of chloroform, dried and recrystallized from aqueous methanol. 7.5 g of white crystalline needles having a melting point of 229° to 230°C were obtained.

brand name

Anhydron (Lilly).

Therapeutic Function

Diuretic, Antihypertensive

Biological Activity

Positive allosteric modulator of AMPA receptors that potently inhibits AMPA receptor desensitization. Selective for the flip variant of each of the four receptor subunits. Also available as part of the AMPA Receptor Tocriset™ .

CYCLOTHIAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products


CYCLOTHIAZIDE Suppliers

Global( 68)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29868 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Dideu Industries Group Limited
029-88380327, 17691182729
service@dideu.com CHINA 29997 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15878 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 279 60
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15424 60
Syntechem Co.,Ltd Please Email
E-Mail Inquiry info@syntechem.com China 13009 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9845 79

View Lastest Price from CYCLOTHIAZIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-08 Cyclothiazide
2259-96-3
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2019-12-30 CYCLOTHIAZIDE
2259-96-3
US $1.00 / g 1g 99% 200kg Career Henan Chemical Co

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