β-Estradiol

Melting point :178-179 °C(lit.)
Boiling point :355.44°C (rough estimate)
alpha :D25 +76 to +83° (dioxane)
Density :1.0708 (rough estimate)
refractive index :80.4 ° (C=1, Dioxane)
Flash point :2℃
storage temp. :room temp
solubility :Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form :powder
pka :pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
color :White to off-white
biological source :synthetic (organic)
Water Solubility :Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck :14,3703
BRN :1914275
Henry's Law Constant :2.7×10⁵ mol/(m³Pa) at 25℃, HSDB (2015)
BCS Class :1
Stability :Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions :SKIN CONDITIONING
InChI :1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChIKey :VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES :O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
CAS DataBase Reference :50-28-2(CAS DataBase Reference)
NIST Chemistry Reference :Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System :Estradiol (50-28-2)

Symbol(GHS):
Signal word:	Danger
Hazard statements:	Code Hazard statements Hazard class Category Signal word Pictogram P-Codes H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501 H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313 H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:	P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P263 Avoid contact during pregnancy/while nursing. P264 Wash hands thoroughly after handling. P264 Wash skin thouroughly after handling. P273 Avoid release to the environment. P308+P313 IF exposed or concerned: Get medical advice/attention.