GNF-2
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- $11 - $2395.3
- Product name: GNF-2
- CAS: 778270-11-4
- MF: C18H13F3N4O2
- MW: 374.32
- EINECS:200-256-5
- MDL Number:MFCD09265253
- Synonyms:3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2;GNF-2 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;GNF 2, >=98%;3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE;Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-;GNF-2;Bcr-abl Inhibitor;3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
65 prices
Selected condition：
Brand
- aablocks
- Abosyn
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5.00mg
- 10mM*1mLinDMSO
- 10.00mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10
- 25.00mg
- 50
- 5g
- 10mM(in1mLDMSO)
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00G3LM
- Product descriptionGNF-2 ≥98%
- Packaging5mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LM
- Product descriptionGNF-2 ≥98%
- Packaging25mg
- Price$39
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LM
- Product descriptionGNF-2 ≥98%
- Packaging50mg
- Price$69
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LM
- Product descriptionGNF-2 98%
- Packaging100mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3LM
- Product descriptionGNF-2 ≥98%
- Packaging250mg
- Price$257
- Updated2026-05-28
- Buy
- ManufacturerAbosyn
- Product number61-11441
- Product description3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 95-98%
- Packaging1g
- Price$890
- Updated2021-12-16
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33972
- Product descriptionGNF-2 98%
- Packaging1G
- Price$540
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33972
- Product descriptionGNF-2 98%
- Packaging100MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5355
- Product descriptionGNF-2
- Packaging100mg
- Price$1660
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging1g
- Price$759
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging250mg
- Price$283
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging50mg
- Price$129
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging100mg
- Price$167
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging2mg
- Price$46
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging5mg
- Price$56
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA175756
- Product descriptionGNF-2 98%
- Packaging1mg
- Price$28
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G3LM | GNF-2 ≥98% | 5mg | $11 | 2026-05-28 | Buy |
| aablocks | AA00G3LM | GNF-2 ≥98% | 25mg | $39 | 2026-05-28 | Buy |
| aablocks | AA00G3LM | GNF-2 ≥98% | 50mg | $69 | 2026-05-28 | Buy |
| aablocks | AA00G3LM | GNF-2 98% | 100mg | $132 | 2026-05-28 | Buy |
| aablocks | AA00G3LM | GNF-2 ≥98% | 250mg | $257 | 2026-05-28 | Buy |
| Abosyn | 61-11441 | 3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 95-98% | 1g | $890 | 2021-12-16 | Buy |
| ACHEMBLOCK | O33972 | GNF-2 98% | 1G | $540 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33972 | GNF-2 98% | 100MG | $110 | 2026-05-27 | Buy |
| AK Scientific | SYN5355 | GNF-2 | 100mg | $1660 | 2021-12-16 | Buy |
| Ambeed | A175756 | GNF-2 98% | 1g | $759 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 250mg | $283 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 50mg | $129 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 100mg | $167 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 2mg | $46 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 5mg | $56 | 2026-06-05 | Buy |
| Ambeed | A175756 | GNF-2 98% | 1mg | $28 | 2026-06-05 | Buy |
Properties
storage temp. :2-8°C
solubility :H2O: <2mg/mL
form :White solid
color :off-white
Water Solubility :H2O: <2mg/mL
DMSO: ≥5mg/mL InChI :1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChIKey :WEVYNIUIFUYDGI-UHFFFAOYSA-N
SMILES :NC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
solubility :H2O: <2mg/mL
form :White solid
color :off-white
Water Solubility :H2O: <2mg/mL
DMSO: ≥5mg/mL InChI :1S/C18H13F3N4O2/c19-18(20,21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H,(H2,22,26)(H,23,24,25)
InChIKey :WEVYNIUIFUYDGI-UHFFFAOYSA-N
SMILES :NC(=O)c1cccc(c1)-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. It demonstrates exclusive antiproliferative activity toward Bcr-Abl-transformed cells (IC50 = 138 nM), inducing apoptosis in these cells without cytotoxic consequences in nontransformed cells.More related product prices
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