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ChemicalBook >> CAS DataBase List >> GS-441524

GS-441524

GS-441524 price.
  • $8 - $2999
  • Product name: GS-441524
  • CAS: 1191237-69-0
  • MF: C12H13N5O4
  • MW: 291.26
  • EINECS:200-001-8
  • MDL Number:MFCD32666994
  • Synonyms:2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDENE)-D-ALTRONONITRI;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-;2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-Altrononitrile;GS441525;(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDRO;GS-441524(EVO984);Remdesivir Impurity 6;S-441524
26 prices
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Brand

  • Adipogen Life Sciences
  • AK Scientific
  • Alichem
  • Ambeed
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Tocris

Package

  • 50
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3722-M010
  • Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3722-M050
  • Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0879AP
  • Product descriptionGS441524
  • Packaging25mg
  • Price$89
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0879AP
  • Product descriptionGS441524
  • Packaging100mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1191237690
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
  • Packaging1g
  • Price$799
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number1191237690
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
  • Packaging5g
  • Price$2999
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging1mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging5mg
  • Price$12
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging10mg
  • Price$16
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging50mg
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging100mg
  • Price$37
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging250mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging1g
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1159246
  • Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
  • Packaging5g
  • Price$464
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0046676
  • Product descriptionGS 441524 95.00%
  • Packaging5MG
  • Price$451.54
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number30469
  • Product descriptionGS-441524
  • Packaging1mg
  • Price$26
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3722-M010 GS-441524(RemdesivirMetabolite) ≥98%(HPLC) 10mg $80 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3722-M050 GS-441524(RemdesivirMetabolite) ≥98%(HPLC) 50mg $210 2021-12-16 Buy
AK Scientific 0879AP GS441524 25mg $89 2021-12-16 Buy
AK Scientific 0879AP GS441524 100mg $250 2021-12-16 Buy
Alichem 1191237690 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 1g $799 2021-12-16 Buy
Alichem 1191237690 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 5g $2999 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 1mg $8 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 5mg $12 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 10mg $16 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 50mg $28 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 100mg $37 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 250mg $55 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 1g $130 2021-12-16 Buy
Ambeed A1159246 (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% 5g $464 2021-12-16 Buy
American Custom Chemicals Corporation API0046676 GS 441524 95.00% 5MG $451.54 2021-12-16 Buy
Cayman Chemical 30469 GS-441524 1mg $26 2024-03-01 Buy

Properties

Melting point :> 233° C (dec.)
Density :1.84±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :12.13±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/s3
InChIKey :BRDWIEOJOWJCLU-QHRJDZJMNA-N
SMILES :C([C@]1(C2=CC=C3C(=NC=NN23)N)[C@@H]([C@H](O)[C@@H](CO)O1)O)#N |&1:1,12,13,15,r|
CAS DataBase Reference :1191237-69-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single-stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as a potential treatment for SARS-CoV-2 infections.

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