GS-441524
- $8 - $2999
- Product name: GS-441524
- CAS: 1191237-69-0
- MF: C12H13N5O4
- MW: 291.26
- EINECS:200-001-8
- MDL Number:MFCD32666994
- Synonyms:2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDENE)-D-ALTRONONITRI;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-;2-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-Altrononitrile;GS441525;(2R,3R,4S,5R)-2-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDRO;GS-441524(EVO984);Remdesivir Impurity 6;S-441524
26 prices
Selected condition:
Brand
- Adipogen Life Sciences
- AK Scientific
- Alichem
- Ambeed
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
Package
- 50
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3722-M010
- Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3722-M050
- Product descriptionGS-441524(RemdesivirMetabolite) ≥98%(HPLC)
- Packaging50mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number0879AP
- Product descriptionGS441524
- Packaging25mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number0879AP
- Product descriptionGS441524
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1191237690
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
- Packaging1g
- Price$799
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number1191237690
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
- Packaging5g
- Price$2999
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging1mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging5mg
- Price$12
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging10mg
- Price$16
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging50mg
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging100mg
- Price$37
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging250mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging1g
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1159246
- Product description(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99%
- Packaging5g
- Price$464
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0046676
- Product descriptionGS 441524 95.00%
- Packaging5MG
- Price$451.54
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number30469
- Product descriptionGS-441524
- Packaging1mg
- Price$26
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Adipogen Life Sciences | AG-CR1-3722-M010 | GS-441524(RemdesivirMetabolite) ≥98%(HPLC) | 10mg | $80 | 2021-12-16 | Buy |
Adipogen Life Sciences | AG-CR1-3722-M050 | GS-441524(RemdesivirMetabolite) ≥98%(HPLC) | 50mg | $210 | 2021-12-16 | Buy |
AK Scientific | 0879AP | GS441524 | 25mg | $89 | 2021-12-16 | Buy |
AK Scientific | 0879AP | GS441524 | 100mg | $250 | 2021-12-16 | Buy |
Alichem | 1191237690 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile | 1g | $799 | 2021-12-16 | Buy |
Alichem | 1191237690 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile | 5g | $2999 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 1mg | $8 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 5mg | $12 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 10mg | $16 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 50mg | $28 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 100mg | $37 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 250mg | $55 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 1g | $130 | 2021-12-16 | Buy |
Ambeed | A1159246 | (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 99% | 5g | $464 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0046676 | GS 441524 95.00% | 5MG | $451.54 | 2021-12-16 | Buy |
Cayman Chemical | 30469 | GS-441524 | 1mg | $26 | 2024-03-01 | Buy |
Properties
Melting point :> 233° C (dec.)
Density :1.84±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :12.13±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/s3
InChIKey :BRDWIEOJOWJCLU-QHRJDZJMNA-N
SMILES :C([C@]1(C2=CC=C3C(=NC=NN23)N)[C@@H]([C@H](O)[C@@H](CO)O1)O)#N |&1:1,12,13,15,r|
CAS DataBase Reference :1191237-69-0
Density :1.84±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :12.13±0.70(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/s3
InChIKey :BRDWIEOJOWJCLU-QHRJDZJMNA-N
SMILES :C([C@]1(C2=CC=C3C(=NC=NN23)N)[C@@H]([C@H](O)[C@@H](CO)O1)O)#N |&1:1,12,13,15,r|
CAS DataBase Reference :1191237-69-0
Safety Information
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Description
GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single-stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as a potential treatment for SARS-CoV-2 infections.More related product prices
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Suppliers and manufacturers
Hubei Ipure Biology Co., Ltd
Henan Tianfu Chemical Co.,Ltd.
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