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ChemicalBook >> CAS DataBase List >> GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII

$44 - $1180
Product name: GSK-3β Inhibitor XVIII
CAS: 1139875-74-3
MF: C20H20ClN5OS
MW: 413.92
EINECS:
MDL Number:MFCD32671859
Synonyms:GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8;(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone

Price17 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
Arctom
Cayman Chemical
ChemScene
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1mg
5mg
10mg
25mg
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100mg

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging1mg
Price$87
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging5mg
Price$179
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging10mg
Price$257
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging25mg
Price$431
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging50mg
Price$603
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EPJQ
Product description(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging100mg
Price$808
Updated2026-05-30
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging100MG
Price$1180
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging25MG
Price$615
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberAD285566
Product descriptionGSK-3 98%
Packaging5MG
Price$235
Updated2026-05-27
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ManufacturerAK Scientific
Product number3559DG
Product description(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone
Packaging25mg
Price$927
Updated2021-12-16
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ManufacturerArctom
Product numberHY-120902
Product descriptionGSK-3Î² inhibitor 8 98.16%
Packaging1mg
Price$98
Updated2026-05-26
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ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging5mg
Price$193
Updated2024-03-01
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ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging10mg
Price$341
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging1mg
Price$44
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21198
Product descriptionGSK3β Inhibitor XVIII
Packaging25mg
Price$745
Updated2024-03-01
Buy

ManufacturerChemScene
Product numberCS-0079556
Product descriptionGSK-3β inhibitor 8 98.16%
Packaging1mg
Price$112
Updated2026-06-04
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	1mg	$87	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	5mg	$179	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	10mg	$257	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	25mg	$431	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	50mg	$603	2026-05-30	Buy
aablocks	AA01EPJQ	(2-Chloro-4-((4-(thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-methylpiperazin-1-yl)methanone	100mg	$808	2026-05-30	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	100MG	$1180	2026-05-27	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	25MG	$615	2026-05-27	Buy
ACHEMBLOCK	AD285566	GSK-3 98%	5MG	$235	2026-05-27	Buy
AK Scientific	3559DG	(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone	25mg	$927	2021-12-16	Buy
Arctom	HY-120902	GSK-3Î² inhibitor 8 98.16%	1mg	$98	2026-05-26	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	5mg	$193	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	10mg	$341	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	1mg	$44	2024-03-01	Buy
Cayman Chemical	21198	GSK3β Inhibitor XVIII	25mg	$745	2024-03-01	Buy
ChemScene	CS-0079556	GSK-3β inhibitor 8 98.16%	1mg	$112	2026-06-04	Buy

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Properties

Boiling point :632.3±65.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6+-.0.10(Predicted)
form :White solid
color :White to off-white

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC₅₀ = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC₅₀ = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

GSK-3β inhibitor 8 CAS:1139875-74-3

Ningbo Chaoming Biotechnology Co., Ltd BOC Sciences BOC Sciences Shanghai EFE Biological Technology Co., Ltd. HANGZHOU CLAP TECHNOLOGY CO.,LTD ChemeGen(Shanghai) Biotechnology Co.,Ltd. Taizhou Nanfeng Pharmaceutical Research Institute Jinan Jiuli Biotechnology Co. , Ltd. TargetMol Chemicals Inc.

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GSK-3β Inhibitor XVIII

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