HERBIMYCIN A
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- $125 - $1231
- Product name: HERBIMYCIN A
- CAS: 70563-58-5
- MF: C30H42N2O9
- MW: 574.66
- EINECS:
- MDL Number:MFCD00151702
- Synonyms:HERBIMYCIN A;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS;HERBIMYCIN A, STREPTOMYCES SPECIES;herbimycin A from streptomyces hygros-copicus;herbimycin A from streptomyces*hygroscopicus;Herbimycin A, Streptomyces sp.;C11225;[(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)-2,5,6,11-Tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl]carbamate
11 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Alfa Aesar
- ApexBio Technology
- Cayman Chemical
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 0.1mg
- 100μg
- 100ug
- 500μg
- 500ug
- 1mg
- 2.5mg
- 100U
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0429-M001
- Product descriptionHerbimycin A, ≥99%(HPLC)
- Packaging1mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ66427
- Product descriptionHerbimycin A, 95%
- Packaging1mg
- Price$962
- Updated2024-03-01
- Buy
- ManufacturerApexBio Technology
- Product numberB6808
- Product descriptionHerbimycin A,
- Packaging500ug
- Price$494
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15504
- Product descriptionHerbimycin A ≥99%
- Packaging500μg
- Price$380
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15504
- Product descriptionHerbimycin A ≥99%
- Packaging2.5mg
- Price$1231
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH6649
- Product descriptionHerbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
- Packaging1mg
- Price$428
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberH6649
- Product descriptionHerbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder
- Packaging0.1mg
- Price$317
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number1629
- Product descriptionHerbimycin A, ≥99%(HPLC)
- Packaging100U
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH288910
- Product descriptionHerbimycin A,
- Packaging100μg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number207220
- Product descriptionHerbimycin A
- Packaging100ug
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberH2030-35A
- Product descriptionHerbimycin A
- Packaging500ug
- Price$523
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0429-M001 | Herbimycin A, ≥99%(HPLC) | 1mg | $590 | 2021-12-16 | Buy |
| Alfa Aesar | J66427 | Herbimycin A, 95% | 1mg | $962 | 2024-03-01 | Buy |
| ApexBio Technology | B6808 | Herbimycin A, | 500ug | $494 | 2021-12-16 | Buy |
| Cayman Chemical | 15504 | Herbimycin A ≥99% | 500μg | $380 | 2024-03-01 | Buy |
| Cayman Chemical | 15504 | Herbimycin A ≥99% | 2.5mg | $1231 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 1mg | $428 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 0.1mg | $317 | 2024-03-01 | Buy |
| Tocris | 1629 | Herbimycin A, ≥99%(HPLC) | 100U | $195 | 2021-12-16 | Buy |
| TRC | H288910 | Herbimycin A, | 100μg | $125 | 2021-12-16 | Buy |
| Usbiological | 207220 | Herbimycin A | 100ug | $358 | 2021-12-16 | Buy |
| Usbiological | H2030-35A | Herbimycin A | 500ug | $523 | 2021-12-16 | Buy |
Properties
Melting point :229-231 °C
Boiling point :752℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :−20°C
solubility :DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
pka :8.56±0.70(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive & Hygroscopic
BRN :4834067
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Boiling point :752℃
Density :1.19±0.1 g/cm3(Predicted)
Flash point :>110°(230°F)
storage temp. :−20°C
solubility :DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
pka :8.56±0.70(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive & Hygroscopic
BRN :4834067
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.Related product price
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