IOX2
|
- $9 - $1654.1
- Product name: IOX2
- CAS: 931398-72-0
- MF: C19H16N2O5
- MW: 352.34
- EINECS:804-733-4
- MDL Number:MFCD22580424
- Synonyms:Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-;N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2;JICL38;N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine;(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine;IOX 2, >=98%;IOX2;IOX 2;IOX-2;JICL38;IOX2
36 prices
Selected condition：
Brand
- Activate Scientific
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mg
- 10
- 5mg
- 25mg
- 50
- 2x5mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerActivate Scientific
- Product numberAS112122
- Product descriptionIOX2 99%
- Packaging25mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS112122
- Product descriptionIOX2 99%
- Packaging100mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ56349
- Product descriptionIOX2
- Packaging25mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0456
- Product descriptionIOX2
- Packaging25mg
- Price$181
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging5mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging10mg
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging50mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging100mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging250mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA114813
- Product description2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+%
- Packaging1g
- Price$241
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001488
- Product descriptionIOX-2 99.00%
- Packaging5MG
- Price$257.4
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4189
- Product descriptionIOX2(Glycine)
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60400
- Product descriptionIOX2 ≥98%
- Packaging10mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1921
- Product descriptionIOX2 100%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146251
- Product descriptionIOX2 >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146251
- Product descriptionIOX2 >98%
- Packaging250mg
- Price$986
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Activate Scientific | AS112122 | IOX2 99% | 25mg | $82 | 2021-12-16 | Buy |
| Activate Scientific | AS112122 | IOX2 99% | 100mg | $188 | 2021-12-16 | Buy |
| AK Scientific | J56349 | IOX2 | 25mg | $135 | 2021-12-16 | Buy |
| AK Scientific | Y0456 | IOX2 | 25mg | $181 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 5mg | $9 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 10mg | $13 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 50mg | $33 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 100mg | $49 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 250mg | $100 | 2021-12-16 | Buy |
| Ambeed | A114813 | 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)aceticacid 99+% | 1g | $241 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001488 | IOX-2 99.00% | 5MG | $257.4 | 2021-12-16 | Buy |
| ApexBio Technology | A4189 | IOX2(Glycine) | 10mg | $90 | 2021-12-16 | Buy |
| Arctom | CFN60400 | IOX2 ≥98% | 10mg | $198 | 2021-12-16 | Buy |
| Axon Medchem | Axon1921 | IOX2 100% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146251 | IOX2 >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146251 | IOX2 >98% | 250mg | $986 | 2021-12-16 | Buy |
Properties
Boiling point :642.8±55.0 °C(Predicted)
Density :1.470±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.61±0.10(Predicted)
form :powder
color :white to beige
InChIKey :CAOSCCRYLYQBES-UHFFFAOYSA-N
Density :1.470±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.61±0.10(Predicted)
form :powder
color :white to beige
InChIKey :CAOSCCRYLYQBES-UHFFFAOYSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Hypoxia-inducible factor (HIF) is regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains in the HIF-1α subunit, which mark it for degradation by the proteasome. HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. They require dioxygen as a cosubstrate, thus acting as the hypoxia-sensing component of the HIF system. The activity of PHD is suppressed by hypoxia, increasing both the abundance and activity of the HIF transcriptional complex. IOX2 potently inhibits PHD2 (IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 μM). IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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