IPA-3
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- $34 - $1200
- Product name: IPA-3
- CAS: 42521-82-4
- MF: C20H14O2S2
- MW: 350.45
- EINECS:
- MDL Number:MFCD00388917
- Synonyms:1,1'-Dithiodi-2-naphthtol;IPA 3;p21-Activated Kinase Inhibitor III, IPA-3;Bis(2-hydroxy-1-naphthyl) disulfide;2-Naphthalenol, 1,1'-dithiobis-;1,1′-Disulfanediyldinaphthalen-2-ol;1,1'-Disulfanediylbis(naphthalen-2-ol);IPA 3;IPA3
30 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 50
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2478AH
- Product description1,1'-Dithiodi-2-naphthtol
- Packaging25mg
- Price$328
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ65848
- Product descriptionp21-Activated Kinase Inhibitor III, IPA-3
- Packaging5mg
- Price$122
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ65848
- Product descriptionp21-Activated Kinase Inhibitor III, IPA-3
- Packaging10mg
- Price$205
- Updated2023-06-20
- Buy
- ManufacturerAmbeed
- Product numberA427173
- Product descriptionIPA-3 98+%
- Packaging5mg
- Price$46
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA427173
- Product descriptionIPA-3 98+%
- Packaging10mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2169
- Product descriptionIPA-3
- Packaging50mg
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60340
- Product descriptionIPA-3 ≥98%
- Packaging10mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14759
- Product descriptionIPA-3 ≥95%
- Packaging5mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14759
- Product descriptionIPA-3 ≥95%
- Packaging10mg
- Price$89
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14759
- Product descriptionIPA-3 ≥95%
- Packaging25mg
- Price$208
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14759
- Product descriptionIPA-3 ≥95%
- Packaging50mg
- Price$330
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1432
- Product descriptionIPA-3 99.43%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1432
- Product descriptionIPA-3 99.43%
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1432
- Product descriptionIPA-3 99.43%
- Packaging50mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1432
- Product descriptionIPA-3 99.43%
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001932
- Product descriptionIPA-3 98+%
- Packaging10mg
- Price$56
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2478AH | 1,1'-Dithiodi-2-naphthtol | 25mg | $328 | 2021-12-16 | Buy |
| Alfa Aesar | J65848 | p21-Activated Kinase Inhibitor III, IPA-3 | 5mg | $122 | 2023-06-20 | Buy |
| Alfa Aesar | J65848 | p21-Activated Kinase Inhibitor III, IPA-3 | 10mg | $205 | 2023-06-20 | Buy |
| Ambeed | A427173 | IPA-3 98+% | 5mg | $46 | 2021-12-16 | Buy |
| Ambeed | A427173 | IPA-3 98+% | 10mg | $69 | 2021-12-16 | Buy |
| ApexBio Technology | B2169 | IPA-3 | 50mg | $273 | 2021-12-16 | Buy |
| Arctom | CFN60340 | IPA-3 ≥98% | 10mg | $188 | 2021-12-16 | Buy |
| Cayman Chemical | 14759 | IPA-3 ≥95% | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 14759 | IPA-3 ≥95% | 10mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 14759 | IPA-3 ≥95% | 25mg | $208 | 2024-03-01 | Buy |
| Cayman Chemical | 14759 | IPA-3 ≥95% | 50mg | $330 | 2024-03-01 | Buy |
| ChemScene | CS-1432 | IPA-3 99.43% | 5mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-1432 | IPA-3 99.43% | 10mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-1432 | IPA-3 99.43% | 50mg | $260 | 2021-12-16 | Buy |
| ChemScene | CS-1432 | IPA-3 99.43% | 100mg | $470 | 2021-12-16 | Buy |
| Crysdot | CD31001932 | IPA-3 98+% | 10mg | $56 | 2021-12-16 | Buy |
Properties
Melting point :172℃
Boiling point :543.7±35.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.52±0.50(Predicted)
form :Yellow solid
color :off-white to yellow
Water Solubility :Soluble in DMSO or ethanol. Insoluble in water.
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :42521-82-4
Boiling point :543.7±35.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.52±0.50(Predicted)
form :Yellow solid
color :off-white to yellow
Water Solubility :Soluble in DMSO or ethanol. Insoluble in water.
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :42521-82-4
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
p21-activated kinase 1 (PAK1) is a member of a family non-receptor serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAK1 results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAK1 expression and activity is upregulated in several human cancers and is a potential therapeutic target for cancer intervention. IPA-3 is a cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.More related product prices
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