LGK-974
|
- $37 - $4090
- Product name: LGK-974
- CAS: 1243244-14-5
- MF: C23H20N6O
- MW: 396.44
- EINECS:
- MDL Number:MFCD27501026
- Synonyms:LGK974(NVP-LGK974);2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide;LGK-974;2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide;2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide;[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-;NVP-LGK974;LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
27 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product number2140AH
- Product description2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
- Packaging1g
- Price$4090
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging10mM(in 1mL DMSO)
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2307
- Product descriptionLGK-974
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60103
- Product descriptionLGK-974(WNT974) ≥98%
- Packaging10mg
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181048
- Product descriptionLGK-974 >98%
- Packaging100mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181048
- Product descriptionLGK-974 >98%
- Packaging250mg
- Price$2097.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181048
- Product descriptionLGK-974 >98%
- Packaging1000mg
- Price$3432.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL76327
- Product descriptionLGK 974
- Packaging50mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL76327
- Product descriptionLGK 974
- Packaging10mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14072
- Product descriptionLGK974 ≥98%
- Packaging500μg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14072
- Product descriptionLGK974 ≥98%
- Packaging1mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14072
- Product descriptionLGK974 ≥98%
- Packaging5mg
- Price$195
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2807
- Product descriptionLGK974 99.74%
- Packaging10mg
- Price$204
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2807
- Product descriptionLGK974 99.74%
- Packaging50mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2807
- Product descriptionLGK974 99.74%
- Packaging100mg
- Price$1128
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2140AH | 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide | 1g | $4090 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 5mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 10mM(in 1mL DMSO) | $140 | 2021-12-16 | Buy |
| ApexBio Technology | B2307 | LGK-974 | 50mg | $640 | 2021-12-16 | Buy |
| Arctom | CFN60103 | LGK-974(WNT974) ≥98% | 10mg | $358 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181048 | LGK-974 >98% | 100mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181048 | LGK-974 >98% | 250mg | $2097.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181048 | LGK-974 >98% | 1000mg | $3432.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL76327 | LGK 974 | 50mg | $473 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL76327 | LGK 974 | 10mg | $135 | 2021-12-16 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 14072 | LGK974 ≥98% | 5mg | $195 | 2024-03-01 | Buy |
| ChemScene | CS-2807 | LGK974 99.74% | 10mg | $204 | 2021-12-16 | Buy |
| ChemScene | CS-2807 | LGK974 99.74% | 50mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-2807 | LGK974 99.74% | 100mg | $1128 | 2021-12-16 | Buy |
Properties
Melting point :176 - 180°C
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White
Boiling point :650.9±55.0 °C(Predicted)
Density :1.268±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.24±0.70(Predicted)
form :Solid
color :White to Off-White
Safety Information
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Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.Related product price
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