LL Z1640-2
|
- $67 - $655
- Product name: LL Z1640-2
- CAS: 253863-19-3
- MF: C19H22O7
- MW: 362.37
- EINECS:
- MDL Number:MFCD12912700
- Synonyms:f 152 A1;C 292;FR148083;L 783279;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;TAK1 inhibitor 5ZO);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;5Z-7-Oxozeaenol >=98% (HPLC)
11 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number3714BB
- Product description5Z-7-Oxozeaenol
- Packaging5mg
- Price$438
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging1mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging5mg
- Price$392
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging10mg
- Price$595
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxo Zeaenol ≥99%
- Packaging1mg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxo Zeaenol ≥99%
- Packaging5mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0012266
- Product description5Z-7-Oxozeaenol >99.0%
- Packaging1mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN21923
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberO9890
- Product description5Z-7-Oxozeaenol ≥98% (HPLC)
- Packaging1mg
- Price$221
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberO870678
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$655
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3714BB | 5Z-7-Oxozeaenol | 5mg | $438 | 2021-12-16 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 1mg | $67 | 2021-12-16 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 5mg | $299 | 2021-12-16 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 5mg | $392 | 2021-12-16 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 10mg | $595 | 2021-12-16 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 1mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 5mg | $299 | 2024-03-01 | Buy |
| ChemScene | CS-0012266 | 5Z-7-Oxozeaenol >99.0% | 1mg | $600 | 2021-12-16 | Buy |
| CSNpharm | CSN21923 | (5Z)-7-Oxozeaenol | 5mg | $550 | 2021-12-16 | Buy |
| Sigma-Aldrich | O9890 | 5Z-7-Oxozeaenol ≥98% (HPLC) | 1mg | $221 | 2024-03-01 | Buy |
| TRC | O870678 | (5Z)-7-Oxozeaenol | 5mg | $655 | 2021-12-16 | Buy |
Properties
Melting point :171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.32±0.70(Predicted)
color :white to off-white
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.32±0.70(Predicted)
color :white to off-white
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1). In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM. (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation. This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.Suppliers and manufacturers
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
ShangHai Caerulum Pharma Discovery Co., Ltd.
Sichuan Wei Keqi Biological Technology Co., Ltd.
Shanghai Macklin Biochemical Co.,Ltd.
Sigma-Aldrich
Beijing Jin Ming Biotechnology Co., Ltd.
Aikon International Limited
