LL Z1640-2
|
- $95 - $3575
- Product name: LL Z1640-2
- CAS: 253863-19-3
- MF: C19H22O7
- MW: 362.37
- EINECS:
- MDL Number:MFCD12912700
- Synonyms:f 152 A1;C 292;FR148083;L 783279;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;TAK1 inhibitor 5ZO);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;5Z-7-Oxozeaenol >=98% (HPLC)
20 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- Manufactureraablocks
- Product numberAA00BE8E
- Product description(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione ≥98%
- Packaging1mg
- Price$428
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD261956
- Product descriptionLL-Z-1640-2 97%
- Packaging1MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD261956
- Product descriptionLL-Z-1640-2 97%
- Packaging5MG
- Price$875
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3714BB
- Product description5Z-7-Oxozeaenol
- Packaging5mg
- Price$438
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$410
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging1mg
- Price$118
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging1mg
- Price$123
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging5mg
- Price$395
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging10mg
- Price$759
- Updated2026-06-04
- Buy
- ManufacturerArctom
- Product numberBD-A493042
- Product description5Z-7-Oxozeaenol 99%
- Packaging1mg
- Price$318
- Updated2026-05-26
- Buy
- ManufacturerBiosynth
- Product numberDKA86319
- Product description(5Z)-7-Oxozeaenol
- Packaging1mg
- Price$306.36
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxozeaenol ≥99%
- Packaging1mg
- Price$95
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxozeaenol ≥99%
- Packaging5mg
- Price$329
- Updated2026-04-30
- Buy
- ManufacturerChemScene
- Product numberCS-0012266
- Product description5Z-7-Oxozeaenol 99.30%
- Packaging1mg
- Price$271
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0012266
- Product description5Z-7-Oxozeaenol 99.30%
- Packaging5mg
- Price$1029
- Updated2026-06-04
- Buy
- ManufacturerChemScene
- Product numberCS-0012266
- Product description5Z-7-Oxozeaenol 99.30%
- Packaging10mg
- Price$1787
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BE8E | (3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione ≥98% | 1mg | $428 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD261956 | LL-Z-1640-2 97% | 1MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD261956 | LL-Z-1640-2 97% | 5MG | $875 | 2026-05-27 | Buy |
| AK Scientific | 3714BB | 5Z-7-Oxozeaenol | 5mg | $438 | 2021-12-16 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 5mg | $410 | 2026-05-06 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 1mg | $118 | 2026-05-06 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 1mg | $123 | 2026-06-04 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 5mg | $395 | 2026-06-04 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 10mg | $759 | 2026-06-04 | Buy |
| Arctom | BD-A493042 | 5Z-7-Oxozeaenol 99% | 1mg | $318 | 2026-05-26 | Buy |
| Biosynth | DKA86319 | (5Z)-7-Oxozeaenol | 1mg | $306.36 | 2026-06-04 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxozeaenol ≥99% | 1mg | $95 | 2026-04-30 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxozeaenol ≥99% | 5mg | $329 | 2026-04-30 | Buy |
| ChemScene | CS-0012266 | 5Z-7-Oxozeaenol 99.30% | 1mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0012266 | 5Z-7-Oxozeaenol 99.30% | 5mg | $1029 | 2026-06-04 | Buy |
| ChemScene | CS-0012266 | 5Z-7-Oxozeaenol 99.30% | 10mg | $1787 | 2026-06-04 | Buy |
Properties
Melting point :171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :7.32±0.70(Predicted)
form :powder
color :white to off-white
InChI :1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
InChIKey :NEQZWEXWOFPKOT-BYRRXHGESA-N
SMILES :COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :7.32±0.70(Predicted)
form :powder
color :white to off-white
InChI :1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1
InChIKey :NEQZWEXWOFPKOT-BYRRXHGESA-N
SMILES :COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1). In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM. (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation. This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.Related product price
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LL Z1640-2
$95-3575 -
Zeaenol
$145-907 -
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