LL Z1640-2
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- $67 - $655
- Product name: LL Z1640-2
- CAS: 253863-19-3
- MF: C19H22O7
- MW: 362.37
- EINECS:
- MDL Number:MFCD12912700
- Synonyms:f 152 A1;C 292;FR148083;L 783279;(2E,5S,6S,8Z,11S)-5,6,15-trihydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaene-7,13-dione;TAK1 inhibitor 5ZO);1H-2-Benzoxacyclotetradecin-1,7(8H)-dione, 3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-, (3S,5Z,8S,9S,11E)-;5Z-7-Oxozeaenol >=98% (HPLC)
11 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Cayman Chemical
- ChemScene
- CSNpharm
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number3714BB
- Product description5Z-7-Oxozeaenol
- Packaging5mg
- Price$438
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging1mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7443
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$299
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging5mg
- Price$392
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIL0128
- Product descriptionLL-Z-1640-2
- Packaging10mg
- Price$595
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxo Zeaenol ≥99%
- Packaging1mg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17459
- Product description(5Z)-7-Oxo Zeaenol ≥99%
- Packaging5mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0012266
- Product description5Z-7-Oxozeaenol >99.0%
- Packaging1mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN21923
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberO9890
- Product description5Z-7-Oxozeaenol ≥98% (HPLC)
- Packaging1mg
- Price$221
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberO870678
- Product description(5Z)-7-Oxozeaenol
- Packaging5mg
- Price$655
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3714BB | 5Z-7-Oxozeaenol | 5mg | $438 | 2021-12-16 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 1mg | $67 | 2021-12-16 | Buy |
| ApexBio Technology | B7443 | (5Z)-7-Oxozeaenol | 5mg | $299 | 2021-12-16 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 5mg | $392 | 2021-12-16 | Buy |
| Apolloscientific | BIL0128 | LL-Z-1640-2 | 10mg | $595 | 2021-12-16 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 1mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 17459 | (5Z)-7-Oxo Zeaenol ≥99% | 5mg | $299 | 2024-03-01 | Buy |
| ChemScene | CS-0012266 | 5Z-7-Oxozeaenol >99.0% | 1mg | $600 | 2021-12-16 | Buy |
| CSNpharm | CSN21923 | (5Z)-7-Oxozeaenol | 5mg | $550 | 2021-12-16 | Buy |
| Sigma-Aldrich | O9890 | 5Z-7-Oxozeaenol ≥98% (HPLC) | 1mg | $221 | 2024-03-01 | Buy |
| TRC | O870678 | (5Z)-7-Oxozeaenol | 5mg | $655 | 2021-12-16 | Buy |
Properties
Melting point :171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.32±0.70(Predicted)
color :white to off-white
Boiling point :666.8±55.0 °C(Predicted)
Density :1.270±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
pka :7.32±0.70(Predicted)
color :white to off-white
Safety Information
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Description
Transforming growth factor-β-activated kinase 1 (TAK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family that activates JNK/p38 and NF-κB pro-inflammatory signaling pathways. (5Z)-7-Oxo zeaenol is a natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein) without significantly affecting the kinase activities of other MAPKKK family members (IC50 = 411 nM for MEK1). In cells, (5Z)-7-oxo zeaenol is reported to irreversibly block IL-1-induced activation of TAK1, NF-κB, and JNK/p38 with IC50 values of 65-83 nM. (5Z)-7-Oxo zeaenol has also been shown to inhibit IL-1-induced COX-2 production in cells and to relieve ear swelling induced by picryl chloride in a mouse model of COX-2-mediated inflammation. This compound has been found to sensitize cells to TRAIL- and TNF-α-induced apoptosis in vitro.Suppliers and manufacturers
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
ShangHai Caerulum Pharma Discovery Co., Ltd.
Sichuan Wei Keqi Biological Technology Co., Ltd.
Sigma-Aldrich
Beijing Jin Ming Biotechnology Co., Ltd.
Aikon International Limited
Beijing OKA biological technology co., LTD
Shenzhen Polymeri Biochemical Technology Co., Ltd.