LONAFARNIB
|
- $33 - $11550
- Product name: LONAFARNIB
- CAS: 193275-84-2
- MF: C27H31Br2ClN4O2
- MW: 638.82
- EINECS:
- MDL Number:MFCD06795138
- Synonyms:LONAFARNIB;4-(2-(4-((R)-3,10-dibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)cyclohexyl)-2-oxoethyl)piperidine-1-carboxaMide;Lonafarnib (SCH66336);1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-B)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-;4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-B)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide;Lonafarnib [usan];Sarasar;Sch 66336
36 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberY0240
- Product descriptionLonafarnib
- Packaging5mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging1mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging5mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging100mg
- Price$708
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging250mg
- Price$1523
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA257211
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
- Packaging1g
- Price$4780
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005242
- Product descriptionLONAFARNIB 95.00%
- Packaging1MG
- Price$161.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005242
- Product descriptionLONAFARNIB 95.00%
- Packaging100MG
- Price$11550
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4379
- Product descriptionLonafarnib
- Packaging10mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4379
- Product descriptionLonafarnib
- Packaging100mg
- Price$1309
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS496892
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
- Packaging1mg
- Price$71
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS496892
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
- Packaging5mg
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS496892
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
- Packaging10mg
- Price$219
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS496892
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
- Packaging100mg
- Price$701
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS496892
- Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
- Packaging250mg
- Price$1508
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y0240 | Lonafarnib | 5mg | $167 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 1mg | $72 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 5mg | $122 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 10mg | $221 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 100mg | $708 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 250mg | $1523 | 2021-12-16 | Buy |
| Ambeed | A257211 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% | 1g | $4780 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005242 | LONAFARNIB 95.00% | 1MG | $161.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005242 | LONAFARNIB 95.00% | 100MG | $11550 | 2021-12-16 | Buy |
| ApexBio Technology | A4379 | Lonafarnib | 10mg | $189 | 2021-12-16 | Buy |
| ApexBio Technology | A4379 | Lonafarnib | 100mg | $1309 | 2021-12-16 | Buy |
| Arctom | AS496892 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 1mg | $71 | 2021-12-16 | Buy |
| Arctom | AS496892 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 5mg | $121 | 2021-12-16 | Buy |
| Arctom | AS496892 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 10mg | $219 | 2021-12-16 | Buy |
| Arctom | AS496892 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 100mg | $701 | 2021-12-16 | Buy |
| Arctom | AS496892 | (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide | 250mg | $1508 | 2021-12-16 | Buy |
Properties
Melting point :214.5-215.9° (monohydrate); mp 222-223°
alpha :D25 = +49.1° (c = 0.21 in methanol)
Boiling point :710.4±70.0 °C(Predicted)
Density :1.536
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.76±0.40(Predicted)
form :powder
color :white to beige
alpha :D25 = +49.1° (c = 0.21 in methanol)
Boiling point :710.4±70.0 °C(Predicted)
Density :1.536
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.76±0.40(Predicted)
form :powder
color :white to beige
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Farnesyl transferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyl transferase inhibitors have great potential as antitumor agents. Lonafarnib is a farnesyl transferase inhibitor that blocks the post-translational lipid modification of oncogenic Ras isoforms H-Ras, N-Ras, and K-Ras (IC50s = 1.9, 2.8, and 5.2 nM, respectively) as well as Rheb (IC50 = 10-100 nM). It inhibits H-Ras signaling in whole cells (IC50 = 10 nM) and blocks the transformed growth properties of fibroblasts (IC50 = 75 nM) and human tumor cell lines (IC50 = 400 nM) expressing activated K-Ras proteins. In the nude mouse, lonafarnib demonstrates potent dose-dependent oral activity in an array of human tumor xenograft models including tumors originating from colon, lung, pancreas, prostate, and urinary bladder. Combination treatments with various cytotoxic agents (cyclophosphamide, 5-fluorouracil, and vincristine) or MAPK or Akt pathway inhibitors can enhance the in vivo efficacy of lonafarib.More related product prices
918504-65-1 Ibrutinib Tipifarnib MK-2206 2HCl Selumetinib Everolimus 14495-51-3Related product price
- 918504-65-1
$29-3960 - Ibrutinib
$5-1208.7 - Tipifarnib
$28-2900
