Losmapimod (GW856553X)
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- $34 - $825
- Product name: Losmapimod (GW856553X)
- CAS: 585543-15-3
- MF: C22H26FN3O2
- MW: 383.46
- EINECS:
- MDL Number:MFCD16619322
- Synonyms:6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide;GW-856553;GSK-AHAB;GW 856553X;LosMapiMod;LosMapiMod,GW-856553;Losmapimod (GW856553X);3-Pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-
24 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 5mg
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 1MG
- 10MG
- 25mg
- ManufacturerAK Scientific
- Product number2523AH
- Product descriptionLosmapimod
- Packaging25mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008145
- Product descriptionLOSMAPIMOD 95.00%
- Packaging1MG
- Price$411
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008145
- Product descriptionLOSMAPIMOD 95.00%
- Packaging10MG
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4620
- Product descriptionLosmapimod
- Packaging10mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4620
- Product descriptionLosmapimod
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4620
- Product descriptionLosmapimod
- Packaging50mg
- Price$269
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC102246
- Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC102246
- Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC102246
- Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- Packaging25mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC102246
- Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- Packaging50mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC102246
- Product description6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
- Packaging100mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13614
- Product descriptionGW 856553X ≥98%
- Packaging1mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13614
- Product descriptionGW 856553X ≥98%
- Packaging5mg
- Price$67
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13614
- Product descriptionGW 856553X ≥98%
- Packaging10mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13614
- Product descriptionGW 856553X ≥98%
- Packaging25mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM178948
- Product description6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-N-neopentylnicotinamide 95+%
- Packaging50mg
- Price$216
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2523AH | Losmapimod | 25mg | $188 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008145 | LOSMAPIMOD 95.00% | 1MG | $411 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008145 | LOSMAPIMOD 95.00% | 10MG | $510 | 2021-12-16 | Buy |
| ApexBio Technology | B4620 | Losmapimod | 10mg | $68 | 2021-12-16 | Buy |
| ApexBio Technology | B4620 | Losmapimod | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | B4620 | Losmapimod | 50mg | $269 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC102246 | 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide | 5mg | $65 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC102246 | 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide | 10mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC102246 | 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide | 25mg | $160 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC102246 | 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide | 50mg | $225 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC102246 | 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide | 100mg | $350 | 2021-12-16 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 5mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 10mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 25mg | $249 | 2024-03-01 | Buy |
| Chemenu | CM178948 | 6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-N-neopentylnicotinamide 95+% | 50mg | $216 | 2021-12-16 | Buy |
Properties
Boiling point :529.4±50.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form :solid
pka :7.75±0.46(Predicted)
color :White to off-white
InChI :InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
InChIKey :KKYABQBFGDZVNQ-UHFFFAOYSA-N
SMILES :C1=NC(C2=CC(C(NC3CC3)=O)=CC(F)=C2C)=CC=C1C(NCC(C)(C)C)=O
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO
form :solid
pka :7.75±0.46(Predicted)
color :White to off-white
InChI :InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
InChIKey :KKYABQBFGDZVNQ-UHFFFAOYSA-N
SMILES :C1=NC(C2=CC(C(NC3CC3)=O)=CC(F)=C2C)=CC=C1C(NCC(C)(C)C)=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Dideu Industries Group Limited
Wuhan Nutra Biotechnology Co.,Ltd
