MK 0557
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- $41 - $2442
- Product name: MK 0557
- CAS: 328232-95-7
- MF: C22H19FN4O3
- MW: 406.41
- EINECS:
- MDL Number:MFCD25976714
- Synonyms:MK 0557;trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide;(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide;Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-;MK0557;MK 0557;CS-2471;N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
40 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250MG
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide ≥98%
- Packaging1mg
- Price$41
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- Packaging5mg
- Price$72
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- Packaging10mg
- Price$99
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- Packaging25mg
- Price$163
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- Packaging50mg
- Price$255
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01EFOO
- Product descriptiontrans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
- Packaging100mg
- Price$351
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32835
- Product descriptionMK 0557 99%
- Packaging100MG
- Price$495
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32835
- Product descriptionMK 0557 99%
- Packaging250MG
- Price$990
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8541CS
- Product descriptionMK-0557
- Packaging5mg
- Price$276
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging10mg
- Price$190
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging10mM*1mLinDMSO(Solution)
- Price$141
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging5mg
- Price$129
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$134
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging200mg
- Price$1102
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging100mg
- Price$808
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15411
- Product descriptionMK-0557 99.80%
- Packaging50mg
- Price$561
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide ≥98% | 1mg | $41 | 2026-05-30 | Buy |
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide | 5mg | $72 | 2026-05-30 | Buy |
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide | 10mg | $99 | 2026-05-30 | Buy |
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide | 25mg | $163 | 2026-05-30 | Buy |
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide | 50mg | $255 | 2026-05-30 | Buy |
| aablocks | AA01EFOO | trans-N-(1-(2-Fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide | 100mg | $351 | 2026-05-30 | Buy |
| ACHEMBLOCK | O32835 | MK 0557 99% | 100MG | $495 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32835 | MK 0557 99% | 250MG | $990 | 2026-05-27 | Buy |
| AK Scientific | 8541CS | MK-0557 | 5mg | $276 | 2021-12-16 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 10mg | $190 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 10mM*1mLinDMSO(Solution) | $141 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 5mg | $129 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 10mM*1mLinDMSO(Solid+Solvent) | $134 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 200mg | $1102 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 100mg | $808 | 2026-05-26 | Buy |
| Arctom | HY-15411 | MK-0557 99.80% | 50mg | $561 | 2026-05-26 | Buy |
Properties
Melting point :240.0-240.6 °C
Boiling point :708.7±60.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form :A crystalline solid
pka :13.40±0.20(Predicted)
color :White to off-white
Boiling point :708.7±60.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form :A crystalline solid
pka :13.40±0.20(Predicted)
color :White to off-white
Safety Information
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Description
MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.More related product prices
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