MK 0557
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- $37 - $2200
- Product name: MK 0557
- CAS: 328232-95-7
- MF: C22H19FN4O3
- MW: 406.41
- EINECS:
- MDL Number:MFCD25976714
- Synonyms:MK 0557;trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide;(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide;N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide;Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-;MK0557;MK 0557;CS-2471;N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
24 prices
Selected condition：
Brand
- AK Scientific
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number8541CS
- Product descriptionMK-0557
- Packaging5mg
- Price$276
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging100mg
- Price$1110
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging200mg
- Price$1510
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging2mg
- Price$140
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging5mg
- Price$210
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging10mg
- Price$300
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging25mg
- Price$530
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb1218162
- Product descriptionMK-0557 >98%(HPLC)
- Packaging50mg
- Price$780
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging25mg
- Price$618
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging25mg
- Price$680
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging10mg
- Price$312
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging5mg
- Price$178
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22134
- Product descriptionMK-0557 ≥98%
- Packaging1mg
- Price$41
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8541CS | MK-0557 | 5mg | $276 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 100mg | $1110 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 200mg | $1510 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 2mg | $140 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 5mg | $210 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 10mg | $300 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 25mg | $530 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1218162 | MK-0557 >98%(HPLC) | 50mg | $780 | 2026-05-06 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 25mg | $618 | 2024-03-01 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 25mg | $680 | 2026-04-30 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 10mg | $312 | 2026-04-30 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22134 | MK-0557 ≥98% | 1mg | $41 | 2026-04-30 | Buy |
Properties
Melting point :240.0-240.6 °C
Boiling point :708.7±60.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form :A crystalline solid
pka :13.40±0.20(Predicted)
color :White to off-white
Boiling point :708.7±60.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
form :A crystalline solid
pka :13.40±0.20(Predicted)
color :White to off-white
Safety Information
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Description
MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at concentrations up to 1 μM. MK-0557 increases intracellular calcium in CHO cells expressing the human Y5 receptor in a concentration-dependent manner. In vivo, MK-0557 (30 mg/kg) reduces body weight gain in wild-type and diet-induced obese mice. It also reduces retroperitoneal fat pad weight, epididymal and mesenteric fat pad weights, leptin levels, and food intake in lean mice fed a high-fat diet.More related product prices
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![trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide](https://img.chemicalbook.com/ProductImageEN/2019-12/small/e89c5389-afcc-487b-9a99-2b0299be145b.jpg){kind=small}
