ML-228
|
- $36 - $2500
- Product name: ML-228
- CAS: 1357171-62-0
- MF: C27H21N5
- MW: 415.49
- EINECS:
- MDL Number:MFCD26792570
- Synonyms:ML-228;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine;ML228; ML 228;N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine;CID-46742353;ML-228;CID-46742353;L-228;1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
45 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- Packaging10mg
- Price$143
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- Packaging25mg
- Price$255
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- Packaging50mg
- Price$372
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- Packaging100mg
- Price$550
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
- Packaging5mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CGF
- Product descriptionN-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine ≥95%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229348
- Product descriptionML228 97.00%
- Packaging50MG
- Price$525
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229348
- Product descriptionML228 97.00%
- Packaging10MG
- Price$180
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3862AH
- Product descriptionN-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
- Packaging50mg
- Price$1197
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML 228
- Packaging100mg
- Price$1050
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML 228
- Packaging10mg
- Price$228
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML 228
- Packaging5mg
- Price$126
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4508
- Product descriptionML 228
- Packaging50mg
- Price$674
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12754
- Product descriptionML228 98.0%
- Packaging100mg
- Price$760
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | 10mg | $143 | 2026-05-28 | Buy |
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | 25mg | $255 | 2026-05-28 | Buy |
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | 50mg | $372 | 2026-05-28 | Buy |
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | 100mg | $550 | 2026-05-28 | Buy |
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine | 5mg | $92 | 2026-05-28 | Buy |
| aablocks | AA009CGF | N-([1,1′-Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine ≥95% | 1mg | $36 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y229348 | ML228 97.00% | 50MG | $525 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y229348 | ML228 97.00% | 10MG | $180 | 2026-05-27 | Buy |
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 5mg | $243 | 2021-12-16 | Buy |
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | 3862AH | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine | 50mg | $1197 | 2021-12-16 | Buy |
| ApexBio Technology | A4508 | ML 228 | 100mg | $1050 | 2026-05-06 | Buy |
| ApexBio Technology | A4508 | ML 228 | 10mg | $228 | 2026-05-06 | Buy |
| ApexBio Technology | A4508 | ML 228 | 5mg | $126 | 2026-05-06 | Buy |
| ApexBio Technology | A4508 | ML 228 | 50mg | $674 | 2026-05-06 | Buy |
| Arctom | HY-12754 | ML228 98.0% | 100mg | $760 | 2026-05-26 | Buy |
Properties
Boiling point :686.0±65.0 °C(Predicted)
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Safety Information
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Description
The hypoxia-inducible factor (HIF) transcription factors are members of the basic-helix-loop-helix (bHLH) family of transcription factors and play important roles in maintaining cellular oxygen homeostasis. HIF-1α has emerged as an important drug target in breast and prostate cancer, cardiovascular disease, and ischemia. ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 μM), HIF-1α nuclear translocation assay (EC50 = 1.3 μM), and increased VEGF expression (EC50 = 1.6 μM). Its activity in the HRE assay is blocked by excess iron, suggesting that ML-228 can chelate iron. Molecular modeling indicates that ML-228 does not modulate HIF signaling by binding to prolyl hydroxyases. ML-228 also significantly inhibits ligand binding to several channels, receptors, and transporters, including ERG potassium channel, 5-HT2B and A3 adenosine receptors, and dopamine transporter.Related product price
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Suppliers and manufacturers
Career Henan Chemica Co
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Beijing Solarbio Science & Tecnology Co., Ltd.
Shanghai Jizhi Biochemical Technology Co. Ltd.
