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ChemicalBook >> CAS DataBase List >> Olaparib

Olaparib

Olaparib price.
  • $28 - $2147.1
  • Product name: Olaparib
  • CAS: 763113-22-0
  • MF: C24H23FN4O3
  • MW: 434.46
  • EINECS:642-941-5
  • MDL Number:MFCD13185161
  • Synonyms:1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin;Olaparid AZD2281;4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]Methyl]-1(2H)-phthalazinone;KU 59436;AZD2281(olaparib)/AZD-2281;AZD2281(olaparib);4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;Olaparib-D8
63 prices
Selected condition:
Brand
  • AccelPharmtech
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 1unit
  • 5mg
  • 10MG
  • 20mg
  • 25mg
  • 50MG
  • 2x25mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1G
  • 2g
  • 5G
  • 10G
  • 25G
  • 10mM(in 1mL DMSO)
  • ManufacturerAccelPharmtech
  • Product numberCF1283
  • Product descriptionOlaparib 99%
  • Packaging1G
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberCF1283
  • Product descriptionOlaparib 99%
  • Packaging5G
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberCF1283
  • Product descriptionOlaparib 99%
  • Packaging10G
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberCF1283
  • Product descriptionOlaparib 99%
  • Packaging25G
  • Price$1910
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-3043-M100
  • Product descriptionOlaparib ≥95%
  • Packaging100mg
  • Price$594
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ93043
  • Product descriptionOlaparib
  • Packaging250mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ93043
  • Product descriptionOlaparib
  • Packaging1g
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberB673
  • Product descriptionOlaparib
  • Packaging1g
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024518
  • Product descriptionOLAPARIB 95.00%
  • Packaging10MG
  • Price$154.35
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024518
  • Product descriptionOLAPARIB 95.00%
  • Packaging50MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4154
  • Product descriptionOlaparib(AZD2281,Ku-0059436)
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4154
  • Product descriptionOlaparib(AZD2281,Ku-0059436)
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4154
  • Product descriptionOlaparib(AZD2281,Ku-0059436)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4154
  • Product descriptionOlaparib(AZD2281,Ku-0059436)
  • Packaging100mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4154
  • Product descriptionOlaparib(AZD2281,Ku-0059436)
  • Packaging500mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60045
  • Product descriptionOlaparib(AZD2281) ≥98%
  • Packaging20mg
  • Price$148
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech CF1283 Olaparib 99% 1G $130 2021-12-16 Buy
AccelPharmtech CF1283 Olaparib 99% 5G $230 2021-12-16 Buy
AccelPharmtech CF1283 Olaparib 99% 10G $1050 2021-12-16 Buy
AccelPharmtech CF1283 Olaparib 99% 25G $1910 2021-12-16 Buy
Adipogen Life Sciences SYN-3043-M100 Olaparib ≥95% 100mg $594 2021-12-16 Buy
AK Scientific J93043 Olaparib 250mg $49 2021-12-16 Buy
AK Scientific J93043 Olaparib 1g $110 2021-12-16 Buy
AK Scientific B673 Olaparib 1g $300 2021-12-16 Buy
American Custom Chemicals Corporation API0024518 OLAPARIB 95.00% 10MG $154.35 2021-12-16 Buy
American Custom Chemicals Corporation API0024518 OLAPARIB 95.00% 50MG $721.88 2021-12-16 Buy
ApexBio Technology A4154 Olaparib(AZD2281,Ku-0059436) 1unit $28 2021-12-16 Buy
ApexBio Technology A4154 Olaparib(AZD2281,Ku-0059436) 10mg $50 2021-12-16 Buy
ApexBio Technology A4154 Olaparib(AZD2281,Ku-0059436) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A4154 Olaparib(AZD2281,Ku-0059436) 100mg $160 2021-12-16 Buy
ApexBio Technology A4154 Olaparib(AZD2281,Ku-0059436) 500mg $480 2021-12-16 Buy
Arctom CFN60045 Olaparib(AZD2281) ≥98% 20mg $148 2021-12-16 Buy

Properties

Density :1.43
storage temp. :-20°C
solubility :Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
pka :12.07±0.40(Predicted)
form :solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES :C1(=O)C2=C(C=CC=C2)C(CC2=CC=C(F)C(C(N3CCN(C(C4CC4)=O)CC3)=O)=C2)=NN1
CAS DataBase Reference :763113-22-0

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

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