PF-6274484
|
- $38 - $4092
- Product name: PF-6274484
- CAS: 1035638-91-5
- MF: C18H14ClFN4O2
- MW: 372.78
- EINECS:
- MDL Number:MFCD30182370
- Synonyms:PF-6274484;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;PF-6274484 >=98% (HPLC);oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor;N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide;PF-6274484, 10 mM in DMSO
27 prices
Selected condition:
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 1G
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging2mg
- Price$48
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging5mg
- Price$64
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging10mg
- Price$95
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging25mg
- Price$178
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging50mg
- Price$316
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENHW
- Product descriptionPF 6274484
- Packaging100mg
- Price$460
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185432
- Product descriptionPF 6274484 95%
- Packaging250MG
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185432
- Product descriptionPF 6274484 95%
- Packaging100MG
- Price$225
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185432
- Product descriptionPF 6274484 95%
- Packaging1G
- Price$1170
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8711DW
- Product descriptionN-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
- Packaging10mg
- Price$302
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8711DW
- Product descriptionN-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
- Packaging5mg
- Price$209
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberKRB63891
- Product descriptionPF-6274484
- Packaging50mg
- Price$1199
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number22698
- Product descriptionPF-6274484 ≥98%
- Packaging1mg
- Price$38
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22698
- Product descriptionPF-6274484 ≥98%
- Packaging10mg
- Price$183
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number22698
- Product descriptionPF-6274484 ≥98%
- Packaging5mg
- Price$110
- Updated2026-04-30
- Buy
- ManufacturerChemenu
- Product numberCM456257
- Product descriptionN-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide 95%+
- Packaging10mg
- Price$903
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01ENHW | PF 6274484 | 2mg | $48 | 2026-05-30 | Buy |
| aablocks | AA01ENHW | PF 6274484 | 5mg | $64 | 2026-05-30 | Buy |
| aablocks | AA01ENHW | PF 6274484 | 10mg | $95 | 2026-05-30 | Buy |
| aablocks | AA01ENHW | PF 6274484 | 25mg | $178 | 2026-05-30 | Buy |
| aablocks | AA01ENHW | PF 6274484 | 50mg | $316 | 2026-05-30 | Buy |
| aablocks | AA01ENHW | PF 6274484 | 100mg | $460 | 2026-05-30 | Buy |
| ACHEMBLOCK | X185432 | PF 6274484 95% | 250MG | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | X185432 | PF 6274484 95% | 100MG | $225 | 2026-05-27 | Buy |
| ACHEMBLOCK | X185432 | PF 6274484 95% | 1G | $1170 | 2026-05-27 | Buy |
| AK Scientific | 8711DW | N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide | 10mg | $302 | 2021-12-16 | Buy |
| AK Scientific | 8711DW | N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide | 5mg | $209 | 2021-12-16 | Buy |
| Biosynth | KRB63891 | PF-6274484 | 50mg | $1199 | 2026-06-04 | Buy |
| Cayman Chemical | 22698 | PF-6274484 ≥98% | 1mg | $38 | 2026-04-30 | Buy |
| Cayman Chemical | 22698 | PF-6274484 ≥98% | 10mg | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 22698 | PF-6274484 ≥98% | 5mg | $110 | 2026-04-30 | Buy |
| Chemenu | CM456257 | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide 95%+ | 10mg | $903 | 2026-05-26 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml
form :A crystalline solid
color :Light yellow to orange
InChI :1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
InChIKey :DTMQCGFVWWBONL-UHFFFAOYSA-N
SMILES :FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32
solubility :DMF: 33 mg/ml; DMSO: 25 mg/ml
form :A crystalline solid
color :Light yellow to orange
InChI :1S/C19H16ClFN4O/c1-4-11(2)24-17-8-13-16(9-18(17)26-3)22-10-23-19(13)25-12-5-6-15(21)14(20)7-12/h4-10,24H,1-2H2,3H3,(H,22,23,25)
InChIKey :DTMQCGFVWWBONL-UHFFFAOYSA-N
SMILES :FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(OC)=C(NC(C=C)=O)C=C32
Safety Information
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Description
PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.More related product prices
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