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PF-6274484

PF-6274484 Structure
PF-6274484 structure
CAS No.
1035638-91-5
Chemical Name:
PF-6274484
Synonyms
PF-6274484;PF-6274484 >=98% (HPLC);N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide;2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-;oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor
CBNumber:
CB14666748
Molecular Formula:
C18H14ClFN4O2
Molecular Weight:
372.78
MDL Number:
MFCD30182370
MOL File:
1035638-91-5.mol
Last updated:2023-09-20 16:43:00
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PF-6274484 Properties

storage temp. Store at -20°C
solubility DMF: 33 mg/ml; DMSO: 25 mg/ml
form A crystalline solid

PF-6274484 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22698 PF-6274484 ≥98% 1035638-91-5 1mg $34 2024-03-01 Buy
Cayman Chemical 22698 PF-6274484 ≥98% 1035638-91-5 5mg $100 2024-03-01 Buy
Cayman Chemical 22698 PF-6274484 ≥98% 1035638-91-5 10mg $166 2024-03-01 Buy
TRC P294153 PF6274484 1035638-91-5 50mg $820 2021-12-16 Buy
AK Scientific 8711DW N-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide 1035638-91-5 5mg $209 2021-12-16 Buy
Product number Packaging Price Buy
22698 1mg $34 Buy
22698 5mg $100 Buy
22698 10mg $166 Buy
P294153 50mg $820 Buy
8711DW 5mg $209 Buy

PF-6274484 Chemical Properties,Uses,Production

Description

PF-6274484 is an irreversible EGFR kinase inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-6274484 inhibits autophosphorylation of both wild type and mutant EGFR in tumor cells with IC50 values of 5.8 nM and 6.6 nM, respectively.

PF-6274484 Preparation Products And Raw materials

Raw materials

Preparation Products

PF-6274484 Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3444 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 3915 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44894 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Energy Chemical 58

PF-6274484 Spectrum

PF-6274484(1035638-91-5)1HNMR

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PF-6274484 N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]- PF-6274484 >=98% (HPLC) oxidation,autophosphorylation,PF6274484,PF-6274484,EGFR,signaling,Epidermal growth factor receptor,HER1,protein,ErbB-1,inhibit,kinase,cysteine,Inhibitor N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)acrylamide 1035638-91-5