PFK-015
|
- $44 - $2499
- Product name: PFK-015
- CAS: 4382-63-2
- MF: C17H12N2O
- MW: 260.29
- EINECS:
- MDL Number:MFCD28099813
- Synonyms:2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;PFK-015;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK015;PFK15;PFK 15;PFK-15;CS-1317;PFK15 (PFK-015)
50 prices
Selected condition：
Brand
- Acints
- Advanced Chemicals Intermediat
- AK Scientific
- Ambeed
- Arctom
- AvaChem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 10mg
- 25mg
- 10mM*1mLinDMSO
- 5mg
- 10mM*1mLinDMSO(Solution)
- 50.00mg
- 50mg
- 100.00mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 250mg
- 250.00mg
- 1g
- 100mg
- 200mg
- 10mM(1mLinDMSO)
- ManufacturerAcints
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging100mg
- Price$202.5
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging250mg
- Price$337.5
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging1g
- Price$702
- Updated2026-05-20
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging1g
- Price$702
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging100mg
- Price$202.5
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-09E-001
- Product description(E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable
- Packaging250mg
- Price$337.5
- Updated2026-05-19
- Buy
- ManufacturerAK Scientific
- Product numberSYN5216
- Product descriptionPFK15
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA131123
- Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
- Packaging1g
- Price$2499
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA131123
- Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
- Packaging100mg
- Price$294
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA131123
- Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
- Packaging50mg
- Price$227
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA131123
- Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
- Packaging5mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA131123
- Product description1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+%
- Packaging10mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSLK-S7289
- Product descriptionPFK15 99.94%
- Packaging10mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7289
- Product descriptionPFK15 99.94%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12204
- Product descriptionPFK-015 99.80%
- Packaging10mg
- Price$101
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12204
- Product descriptionPFK-015 99.80%
- Packaging25mg
- Price$202
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Acints | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 100mg | $202.5 | 2026-05-20 | Buy |
| Acints | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 250mg | $337.5 | 2026-05-20 | Buy |
| Acints | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 1g | $702 | 2026-05-20 | Buy |
| Advanced Chemicals Intermediat | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 1g | $702 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 100mg | $202.5 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | ATI-09E-001 | (E)-1-Pyridin-4-yl-3-quinolin-2-yl-propenone Notavailable | 250mg | $337.5 | 2026-05-19 | Buy |
| AK Scientific | SYN5216 | PFK15 | 100mg | $650 | 2021-12-16 | Buy |
| Ambeed | A131123 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% | 1g | $2499 | 2021-12-16 | Buy |
| Ambeed | A131123 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% | 100mg | $294 | 2021-12-16 | Buy |
| Ambeed | A131123 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% | 50mg | $227 | 2021-12-16 | Buy |
| Ambeed | A131123 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% | 5mg | $104 | 2021-12-16 | Buy |
| Ambeed | A131123 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one 98+% | 10mg | $135 | 2021-12-16 | Buy |
| Arctom | SLK-S7289 | PFK15 99.94% | 10mg | $140 | 2026-05-26 | Buy |
| Arctom | SLK-S7289 | PFK15 99.94% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
| Arctom | HY-12204 | PFK-015 99.80% | 10mg | $101 | 2026-05-26 | Buy |
| Arctom | HY-12204 | PFK-015 99.80% | 25mg | $202 | 2026-05-26 | Buy |
Properties
Boiling point :464.4±45.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :3.11±0.61(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChIKey :UJJUKZPBUMCSJZ-BQYQJAHWSA-N
SMILES :n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :3.11±0.61(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChIKey :UJJUKZPBUMCSJZ-BQYQJAHWSA-N
SMILES :n1ccc(cc1)C(=O)\C=C\c2nc3c(cc2)cccc3
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types. PFK15 is a selective inhibitor of PFKFB3 (IC50 = 207 nM). It has no significant inhibitory effect on any member of a panel of 96 other kinases, and does not inhibit purified 6-phosphofructo-1-kinase, hexokinase, phosphoglucose isomerase, or PFKFB4. PFK15 rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.More related product prices
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