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ChemicalBook >> CAS DataBase List >> RG108

RG108

RG108 price.
  • $20 - $2416
  • Product name: RG108
  • CAS: 48208-26-0
  • MF: C19H14N2O4
  • MW: 334.33
  • EINECS:
  • MDL Number:MFCD08705332
  • Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan
Price82 Properties Safety Information Description
82 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • Thermo Scientific Chemicals
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
  • 5mg
  • 10mM*1mLinDMSO(Solution)
  • 10mg
  • 20mg
  • 25mg
  • 10mM*1mLinDMSO
  • 2x10mg
  • 10mM(in1mLDMSO)
  • 50mg
  • 100mg
  • 2x50mg
  • 500mg
  • 50.00g
  • 100.00g
  • 250.00g
  • 10mM(in 1mL DMSO)
  • 200MG
  • 250mg
  • 1g
  • 5g
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 98%
  • Packaging1mg
  • Price$20
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 98%
  • Packaging5mg
  • Price$29
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 98%
  • Packaging10mg
  • Price$36
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 98%
  • Packaging50mg
  • Price$53
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 95%
  • Packaging100mg
  • Price$55
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 95%
  • Packaging250mg
  • Price$116
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 97%
  • Packaging1g
  • Price$402
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003U1M
  • Product descriptionN-Phthalyl-L-tryptophan 97%
  • Packaging5g
  • Price$1564
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33720
  • Product descriptionRG108 98%
  • Packaging5G
  • Price$1250
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33720
  • Product descriptionRG108 98%
  • Packaging1G
  • Price$350
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO33720
  • Product descriptionRG108 98%
  • Packaging100MG
  • Price$95
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN3037
  • Product descriptionRG-108
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging100mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging50mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging10mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA548158
  • Product descriptionRG108 98+%
  • Packaging5mg
  • Price$42
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 98% 1mg $20 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 98% 5mg $29 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 98% 10mg $36 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 98% 50mg $53 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 95% 100mg $55 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 95% 250mg $116 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 97% 1g $402 2026-05-28 Buy
aablocks AA003U1M N-Phthalyl-L-tryptophan 97% 5g $1564 2026-05-28 Buy
ACHEMBLOCK O33720 RG108 98% 5G $1250 2026-05-27 Buy
ACHEMBLOCK O33720 RG108 98% 1G $350 2026-05-27 Buy
ACHEMBLOCK O33720 RG108 98% 100MG $95 2026-05-27 Buy
AK Scientific SYN3037 RG-108 10mg $130 2021-12-16 Buy
Ambeed A548158 RG108 98+% 100mg $111 2021-12-16 Buy
Ambeed A548158 RG108 98+% 50mg $88 2021-12-16 Buy
Ambeed A548158 RG108 98+% 10mg $55 2021-12-16 Buy
Ambeed A548158 RG108 98+% 5mg $42 2021-12-16 Buy
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Properties

Melting point :192-194℃
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
optical activity :[α]/D -250 to -310°, c =0.5 in methanol
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1
InChIKey :LMAZUAXDZRILNJ-INIZCTEOSA-N
SMILES :OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O
CAS DataBase Reference :48208-26-0

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.

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Suppliers and manufacturers

J & K SCIENTIFIC LTD. 3B Pharmachem (Wuhan) International Co.,Ltd. TCI (Shanghai) Development Co., Ltd. VDM Biochemicals Jinan Trio PharmaTech Co., Ltd. Shandong Xiya Chemical Co., Ltd China Langchem Inc. Dalian Meilun Biotech Co., Ltd. Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Haoyuan Chemexpress Co., Ltd.