RKI1447
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- $32 - $2691.1
- Product name: RKI1447
- CAS: 1342278-01-6
- MF: C16H14N4O2S
- MW: 326.37
- EINECS:200-256-5
- MDL Number:MFCD26142658
- Synonyms:RKI1447;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-;1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447;RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea;RKI-1447, >=98%;CS-855;RKI 1447; RKI1447
55 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10.00mg
- 50.00mg
- 100.00mg
- 1000mg
- 1g
- 10mM*1mLinDMSO
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA009CBT
- Product descriptionUrea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99%
- Packaging1mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBT
- Product descriptionUrea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBT
- Product descriptionUrea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- ≥98%
- Packaging10mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBT
- Product descriptionUrea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99%
- Packaging50mg
- Price$157
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CBT
- Product descriptionUrea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99%
- Packaging100mg
- Price$189
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging100MG
- Price$360
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging250MG
- Price$655
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY1875
- Product descriptionRKI-1447
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging50mg
- Price$297
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging25mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mM(in1mLDMSO)
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mg
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mM(in 1mL DMSO)
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-15755
- Product descriptionRKI-1447 98.02%
- Packaging10mg
- Price$105
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15755
- Product descriptionRKI-1447 98.02%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$60
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CBT | Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99% | 1mg | $32 | 2026-05-28 | Buy |
| aablocks | AA009CBT | Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA009CBT | Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- ≥98% | 10mg | $53 | 2026-05-28 | Buy |
| aablocks | AA009CBT | Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99% | 50mg | $157 | 2026-05-28 | Buy |
| aablocks | AA009CBT | Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 99% | 100mg | $189 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33901 | RKI-1447 98% | 100MG | $360 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33901 | RKI-1447 98% | 250MG | $655 | 2026-05-27 | Buy |
| AK Scientific | Y1875 | RKI-1447 | 50mg | $522 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 50mg | $297 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 25mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mg | $79 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mM(in 1mL DMSO) | $99 | 2021-12-16 | Buy |
| Arctom | HY-15755 | RKI-1447 98.02% | 10mg | $105 | 2026-05-26 | Buy |
| Arctom | HY-15755 | RKI-1447 98.02% | 10mM*1mLinDMSO(Solid+Solvent) | $60 | 2026-05-26 | Buy |
Properties
Melting point :>205oC (dec.)
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
InChI :InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey :GDVRVPIXWXOKQO-UHFFFAOYSA-N
SMILES :N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
InChI :InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey :GDVRVPIXWXOKQO-UHFFFAOYSA-N
SMILES :N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).More related product prices
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Suppliers and manufacturers
Shanghai Chaolan Chemical Technology Center
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
Shanghai Hanhong Scientific Co.,Ltd.
Jinan Trio PharmaTech Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
Shanghai Topbiochem Technology Co., Ltd
Haoyuan Chemexpress Co., Ltd.
Shanghai Aladdin Bio-Chem Technology Co.,LTD
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD