RKI1447
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- $55 - $2691.1
- Product name: RKI1447
- CAS: 1342278-01-6
- MF: C16H14N4O2S
- MW: 326.37
- EINECS:200-256-5
- MDL Number:MFCD26142658
- Synonyms:RKI1447;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-;1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447;RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea;RKI-1447, >=98%;CS-855;RKI 1447; RKI1447
70 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
Package
- 10mM*1mLinDMSO
- 10.00mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 50.00mg
- 100.00mg
- 100MG
- 1g
- 1000mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 25mg
- 50mg
- 250MG
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 10mM(in1mLDMSO)
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging100MG
- Price$360
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging100MG
- Price$360
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging250MG
- Price$655
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33901
- Product descriptionRKI-1447 98%
- Packaging250MG
- Price$655
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberY1875
- Product descriptionRKI-1447
- Packaging50mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging50mg
- Price$297
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mM(in1mLDMSO)
- Price$61
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mg
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mM(in 1mL DMSO)
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging25mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3771
- Product descriptionRKI-1447
- Packaging25mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-15755
- Product descriptionRKI-1447 98.02%
- Packaging10mg
- Price$105
- Updated2026-05-25
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | O33901 | RKI-1447 98% | 100MG | $360 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33901 | RKI-1447 98% | 100MG | $360 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33901 | RKI-1447 98% | 250MG | $655 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33901 | RKI-1447 98% | 250MG | $655 | 2026-05-27 | Buy |
| AK Scientific | Y1875 | RKI-1447 | 50mg | $522 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 50mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 50mg | $297 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mM(in1mLDMSO) | $61 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mg | $79 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mM(in 1mL DMSO) | $99 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 10mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 25mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | A3771 | RKI-1447 | 25mg | $240 | 2021-12-16 | Buy |
| Arctom | HY-15755 | RKI-1447 98.02% | 10mg | $105 | 2026-05-25 | Buy |
Properties
Melting point :>205oC (dec.)
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
InChI :InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey :GDVRVPIXWXOKQO-UHFFFAOYSA-N
SMILES :N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O
Density :1.408±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :6.36±0.70(Predicted)
form :Solid
color :Pale Yellow to Pale Beige
InChI :InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey :GDVRVPIXWXOKQO-UHFFFAOYSA-N
SMILES :N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).More related product prices
AZD-9291 864082-47-3 Fasudil hydrochloride 1,9-Pyrazoloanthrone Thiazovivin RN486 946387-07-1 RN-1 (hydrochloride) Y27632 (hydrochloride)Related product price
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