Refametinib
|
- $16 - $11250
- Product name: Refametinib
- CAS: 923032-37-5
- MF: C19H20F3IN2O5S
- MW: 572.34
- EINECS:
- MDL Number:MFCD18633256
- Synonyms:RDEA119;BAY-869766;RefaMetinib;RDEA-119 (BAY-869766);BAY 8697661;RefaMetinib/BAY 8697661;N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide;(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
45 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mg
- 10mM*1mLinDMSO(Solution)
- 25mg
- 50mg
- 100MG
- 200mg
- 250MG
- 1G
- 5000mg
- Manufactureraablocks
- Product numberAA00GR9W
- Product descriptionN-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99%
- Packaging10mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GR9W
- Product descriptionN-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GR9W
- Product descriptionN-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99%
- Packaging5mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GR9W
- Product descriptionN-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99%
- Packaging50mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GR9W
- Product descriptionN-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99
- Packaging200mg
- Price$451
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32834
- Product descriptionRefametinib 98%
- Packaging100MG
- Price$635
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32834
- Product descriptionRefametinib 98%
- Packaging250MG
- Price$1270
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32834
- Product descriptionRefametinib 98%
- Packaging1G
- Price$3300
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5691
- Product descriptionRDEA119
- Packaging100mg
- Price$931
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging200mg
- Price$760
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging100mg
- Price$470
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging50mg
- Price$290
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging10mg
- Price$105
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging5mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBISN0230
- Product descriptionRefametinib 99%
- Packaging50mg
- Price$204
- Updated2026-06-04
- Buy
- ManufacturerArctom
- Product numberCFN60397
- Product descriptionRefametinib(RDEA119)
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GR9W | N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99% | 10mg | $46 | 2026-05-28 | Buy |
| aablocks | AA00GR9W | N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA00GR9W | N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99% | 5mg | $33 | 2026-05-28 | Buy |
| aablocks | AA00GR9W | N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99% | 50mg | $132 | 2026-05-28 | Buy |
| aablocks | AA00GR9W | N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide 99 | 200mg | $451 | 2026-05-28 | Buy |
| ACHEMBLOCK | O32834 | Refametinib 98% | 100MG | $635 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32834 | Refametinib 98% | 250MG | $1270 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32834 | Refametinib 98% | 1G | $3300 | 2026-05-27 | Buy |
| AK Scientific | SYN5691 | RDEA119 | 100mg | $931 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 200mg | $760 | 2026-05-06 | Buy |
| ApexBio Technology | B1267 | Refametinib | 100mg | $470 | 2026-05-06 | Buy |
| ApexBio Technology | B1267 | Refametinib | 50mg | $290 | 2026-05-06 | Buy |
| ApexBio Technology | B1267 | Refametinib | 10mg | $105 | 2026-05-06 | Buy |
| ApexBio Technology | B1267 | Refametinib | 5mg | $70 | 2026-05-06 | Buy |
| Apolloscientific | BISN0230 | Refametinib 99% | 50mg | $204 | 2026-06-04 | Buy |
| Arctom | CFN60397 | Refametinib(RDEA119) | 10mg | $208 | 2021-12-16 | Buy |
Properties
Boiling point :566.9±60.0 °C(Predicted)
Density :1.82±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form :Powder
pka :15.54±0.20(Predicted)
color :White to yellow
Density :1.82±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form :Powder
pka :15.54±0.20(Predicted)
color :White to yellow
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||
| Precautionary statements: |
|
Description
Refametinib is an allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively). It blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM), inhibiting cell cycling in cancer cells but not in primary cells. Refametinib is orally available and active in human tumor xenograft models. It has potential utility, particularly in combination therapy, in certain forms of cancer.Related product price
-
Olaparib
$11-2994.75 -
Rapamycin
$9-6160 -
PD 0332991 HCl
$16-1208.7
Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Jinan Trio PharmaTech Co., Ltd.
NCE Biomedical Co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
Bide Pharmatech Ltd.
AdooQ Bioscience CHINA
Guangzhou Ciming Biological Technology Co., Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
Watson Biotechnology Co.,Ltd