SCH772984
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- $37 - $2400
- Product name: SCH772984
- CAS: 942183-80-4
- MF: C33H33N9O2
- MW: 587.67
- EINECS:1592732-453-0
- MDL Number:MFCD11878503
- Synonyms:SCH772984;SCH772984/SCH-772984;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide;(3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide SCH772984;(R)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-;SCH772984, >=98%;(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indaz
29 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5640
- Product descriptionSCH772984
- Packaging100mg
- Price$1660
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging2mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging5mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging10mg
- Price$161
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging50mg
- Price$482
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging100mg
- Price$660
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging250mg
- Price$792
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA378792
- Product description(R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+%
- Packaging1g
- Price$1980
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3805
- Product descriptionSCH772984
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60064
- Product descriptionSCH772984
- Packaging5mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181138
- Product descriptionSCH-772984 >98%
- Packaging100mg
- Price$765
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181138
- Product descriptionSCH-772984 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS157995
- Product descriptionSCH 772984
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFS157995
- Product descriptionSCH 772984
- Packaging50mg
- Price$612.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19166
- Product descriptionSCH 772984 ≥95%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19166
- Product descriptionSCH 772984 ≥95%
- Packaging5mg
- Price$161
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5640 | SCH772984 | 100mg | $1660 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 2mg | $63 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 5mg | $107 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 10mg | $161 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 50mg | $482 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 100mg | $660 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 250mg | $792 | 2021-12-16 | Buy |
| Ambeed | A378792 | (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide 98+% | 1g | $1980 | 2021-12-16 | Buy |
| ApexBio Technology | A3805 | SCH772984 | 10mg | $180 | 2021-12-16 | Buy |
| Arctom | CFN60064 | SCH772984 | 5mg | $260 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181138 | SCH-772984 >98% | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181138 | SCH-772984 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS157995 | SCH 772984 | 10mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FS157995 | SCH 772984 | 50mg | $612.5 | 2021-12-16 | Buy |
| Cayman Chemical | 19166 | SCH 772984 ≥95% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19166 | SCH 772984 ≥95% | 5mg | $161 | 2024-03-01 | Buy |
Properties
Melting point :>214°C (dec.)
Boiling point :857.3±65.0 °C(Predicted)
Density :1.353±0.06(20.0000℃)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
pka :12.05±0.40(Predicted)
form :Solid
color :Pale Yellow
CAS DataBase Reference :942183-80-4
Boiling point :857.3±65.0 °C(Predicted)
Density :1.353±0.06(20.0000℃)
storage temp. :Refrigerator
solubility :DMSO (Slightly)
pka :12.05±0.40(Predicted)
form :Solid
color :Pale Yellow
CAS DataBase Reference :942183-80-4
Safety Information
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Description
The extracellular regulated kinases 1 and 2 (ERK1/2) are functionally redundant kinases activated by a variety of growth factors and mitogens. SCH 772984 is a potent inhibitor of ERK1 and ERK2 (IC50s = 4 and 1 nM, respectively). It is highly selective, with only seven kinases of 300 tested showing more than 50% inhibition at a concentration of 1 μM. SCH 772984 has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. It is effective in vivo, inducing regression of xenograft tumors in mice. SCH 772984 displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.Related product price
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