TC 14012
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- $99 - $1097
- Product name: TC 14012
- CAS: 368874-34-4
- MF: C90H140N34O19S2
- MW: 2066.42
- EINECS:
- MDL Number:MFCD19690961
- Synonyms:TC 14012;L-Argininamide, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-N5-(aminocarbonyl)-D-ornithyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide;SGDDHDBBOJNZKY-LNDHEDFZSA-N;TC 14012 （TFA ）;TC 14012, Peptidomimetic CXCR4 antagonist
6 prices
Selected condition：
Brand
- ApexBio Technology
- Cayman Chemical
- Tocris
- Usbiological
Package
- 5mg
- 1
- 1mg
- 10mg
- ManufacturerApexBio Technology
- Product numberB7639
- Product descriptionTC14012
- Packaging10mg
- Price$1097
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11974
- Product descriptionTC 14012 ≥95%
- Packaging1mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11974
- Product descriptionTC 14012 ≥95%
- Packaging5mg
- Price$446
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11974
- Product descriptionTC 14012 ≥95%
- Packaging10mg
- Price$792
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4300
- Product descriptionTC14012
- Packaging1
- Price$266
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number256819
- Product descriptionTC 14012
- Packaging1mg
- Price$516
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | B7639 | TC14012 | 10mg | $1097 | 2021-12-16 | Buy |
| Cayman Chemical | 11974 | TC 14012 ≥95% | 1mg | $99 | 2021-12-16 | Buy |
| Cayman Chemical | 11974 | TC 14012 ≥95% | 5mg | $446 | 2021-12-16 | Buy |
| Cayman Chemical | 11974 | TC 14012 ≥95% | 10mg | $792 | 2021-12-16 | Buy |
| Tocris | 4300 | TC14012 | 1 | $266 | 2021-12-16 | Buy |
| Usbiological | 256819 | TC 14012 | 1mg | $516 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -80°C
solubility :Methanol (Slightly), Water (Slightly)
form :Powder
color :White to off-white
Water Solubility :Soluble to 1 mg/ml in water
Stability :Hygroscopic
solubility :Methanol (Slightly), Water (Slightly)
form :Powder
color :White to off-white
Water Solubility :Soluble to 1 mg/ml in water
Stability :Hygroscopic
Safety Information
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Description
C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. TC 14012 is an antagonist of CXCR4, blocking CXCR4-mediated HIV infection with an IC50 value of 19.3 nM. In addition, TC 14012 (100 μg/ml) inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3 in B cells from patients with chronic lymphocytic leukemia. This peptidomimetic is C-terminally amidated, resulting in high stability in serum. TC 14012 also activates CXCR7 (EC50 = 350 nM), resulting in the recruitment of β-arrestin and Erk ? phosphorylation.Suppliers and manufacturers
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