UNC 0224
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- $48 - $1800
- Product name: UNC 0224
- CAS: 1197196-48-7
- MF: C26H43N7O2
- MW: 485.67
- EINECS:
- MDL Number:MFCD18251564
- Synonyms:UNC 0224;4-QuinazolinaMine, 7-[3-(diMethylaMino)propoxy]-2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6-Methoxy-N-(1-Methyl-4-piperidinyl)-;N-Debenzyl-N-Methyl-O-deMethyl-O-(3-diMethylaMinopropyl)-BIX 01294;CS-1635;UNC-0224; UNC0224; UNC 0224;7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine;K373,G9a,UNC0224,PKMT,lysine,UNC 0224,SAR,stabilized,p53,inhibit,quinazoline,H3K9,UNC-0224,GLP,Inhibitor,Histone Methyltransferase,chromatin
22 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number4141AH
- Product description7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
- Packaging10mg
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4503
- Product descriptionUNC0224
- Packaging10mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4503
- Product descriptionUNC0224
- Packaging50mg
- Price$618
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging5mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging10mg
- Price$223
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging25mg
- Price$507
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1789
- Product descriptionUNC0224 99%
- Packaging5mg
- Price$93.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging1mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging10mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging50mg
- Price$936
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging5mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging50mg
- Price$840
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004330
- Product descriptionUNC0224 98+%
- Packaging25mg
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004330
- Product descriptionUNC0224 98+%
- Packaging50mg
- Price$665
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4141AH | 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine | 10mg | $253 | 2021-12-16 | Buy |
| ApexBio Technology | A4503 | UNC0224 | 10mg | $147 | 2021-12-16 | Buy |
| ApexBio Technology | A4503 | UNC0224 | 50mg | $618 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 5mg | $149 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 10mg | $223 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 25mg | $507 | 2021-12-16 | Buy |
| Axon Medchem | Axon1789 | UNC0224 99% | 5mg | $93.5 | 2021-12-16 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 50mg | $936 | 2024-03-01 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 5mg | $116 | 2021-12-16 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 50mg | $840 | 2021-12-16 | Buy |
| Crysdot | CD31004330 | UNC0224 98+% | 25mg | $351 | 2021-12-16 | Buy |
| Crysdot | CD31004330 | UNC0224 98+% | 50mg | $665 | 2021-12-16 | Buy |
Properties
Boiling point :641.0±65.0 °C(Predicted)
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form :Powder
pka :9.34±0.70(Predicted)
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form :Powder
pka :9.34±0.70(Predicted)
Safety Information
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Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).Related product price
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