UNC 0224
|
- $48 - $1800
- Product name: UNC 0224
- CAS: 1197196-48-7
- MF: C26H43N7O2
- MW: 485.67
- EINECS:
- MDL Number:MFCD18251564
- Synonyms:UNC 0224;4-QuinazolinaMine, 7-[3-(diMethylaMino)propoxy]-2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6-Methoxy-N-(1-Methyl-4-piperidinyl)-;N-Debenzyl-N-Methyl-O-deMethyl-O-(3-diMethylaMinopropyl)-BIX 01294;CS-1635;UNC-0224; UNC0224; UNC 0224;7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine;7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine;K373,G9a,UNC0224,PKMT,lysine,UNC 0224,SAR,stabilized,p53,inhibit,quinazoline,H3K9,UNC-0224,GLP,Inhibitor,Histone Methyltransferase,chromatin
22 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number4141AH
- Product description7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
- Packaging10mg
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4503
- Product descriptionUNC0224
- Packaging10mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4503
- Product descriptionUNC0224
- Packaging50mg
- Price$618
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging5mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging10mg
- Price$223
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0023
- Product descriptionUNC0224
- Packaging25mg
- Price$507
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1789
- Product descriptionUNC0224 99%
- Packaging5mg
- Price$93.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging1mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging10mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13631
- Product descriptionUNC0224 ≥98%
- Packaging50mg
- Price$936
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging5mg
- Price$116
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2210
- Product descriptionUNC0224 99.31%
- Packaging50mg
- Price$840
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004330
- Product descriptionUNC0224 98+%
- Packaging25mg
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004330
- Product descriptionUNC0224 98+%
- Packaging50mg
- Price$665
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4141AH | 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine | 10mg | $253 | 2021-12-16 | Buy |
| ApexBio Technology | A4503 | UNC0224 | 10mg | $147 | 2021-12-16 | Buy |
| ApexBio Technology | A4503 | UNC0224 | 50mg | $618 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 5mg | $149 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 10mg | $223 | 2021-12-16 | Buy |
| Apolloscientific | BISN0023 | UNC0224 | 25mg | $507 | 2021-12-16 | Buy |
| Axon Medchem | Axon1789 | UNC0224 99% | 5mg | $93.5 | 2021-12-16 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 13631 | UNC0224 ≥98% | 50mg | $936 | 2024-03-01 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 5mg | $116 | 2021-12-16 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-2210 | UNC0224 99.31% | 50mg | $840 | 2021-12-16 | Buy |
| Crysdot | CD31004330 | UNC0224 98+% | 25mg | $351 | 2021-12-16 | Buy |
| Crysdot | CD31004330 | UNC0224 98+% | 50mg | $665 | 2021-12-16 | Buy |
Properties
Boiling point :641.0±65.0 °C(Predicted)
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form :Powder
pka :9.34±0.70(Predicted)
color :White to yellow
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
form :Powder
pka :9.34±0.70(Predicted)
color :White to yellow
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).Related product price
- CB92592812
$38-665 - UNC0379
$74-1600 - UNC 1999
$32-3876
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
Soochow Chirally Material Science and Technology Co.,Ltd
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
