WP1066
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- $8 - $1647
- Product name: WP1066
- CAS: 857064-38-1
- MF: C17H14BrN3O
- MW: 356.22
- EINECS:
- MDL Number:MFCD12912450
- Synonyms:WP1066;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide;WP1066/WP-1066;(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066;WP1066, >=99%;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
78 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 10mM*1mLinDMSO
- 10mM(in1mLDMSO)
- 1unit
- 5MG
- 10mg
- 25mg
- 50mg
- 2x50mg
- 100mg
- 250.00mg
- 10mM(in 1mL DMSO)
- 250mg
- 500mg
- 1g
- 1.00g
- 1000mg
- 5.00g
- EvaluationSample
- 5G
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98%
- Packaging250mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98%
- Packaging100mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98%
- Packaging1g
- Price$171
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide ≥98%
- Packaging50mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide ≥98%
- Packaging10mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA004ZIZ
- Product description(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98%
- Packaging1mg
- Price$8
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberT97985
- Product descriptionWP1066 98%
- Packaging1G
- Price$215
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT97985
- Product descriptionWP1066 98%
- Packaging1G
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT97985
- Product descriptionWP1066 98%
- Packaging5G
- Price$860
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT97985
- Product descriptionWP1066 98%
- Packaging5G
- Price$860
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5924
- Product descriptionWP1066
- Packaging50mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5924
- Product descriptionWP1066 98%(HPLC)
- Packaging250mg
- Price$99
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX5924
- Product descriptionWP1066 98%(HPLC)
- Packaging100mg
- Price$60
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberX5924
- Product descriptionWP1066 98%(HPLC)
- Packaging25mg
- Price$21
- Updated2026-06-04
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001256
- Product descriptionWP1066 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001256
- Product descriptionWP1066 95.00%
- Packaging5MG
- Price$698.02
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98% | 250mg | $64 | 2026-05-28 | Buy |
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98% | 100mg | $38 | 2026-05-28 | Buy |
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98% | 1g | $171 | 2026-05-28 | Buy |
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide ≥98% | 50mg | $22 | 2026-05-28 | Buy |
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide ≥98% | 10mg | $10 | 2026-05-28 | Buy |
| aablocks | AA004ZIZ | (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide 98% | 1mg | $8 | 2026-05-28 | Buy |
| ACHEMBLOCK | T97985 | WP1066 98% | 1G | $215 | 2026-05-25 | Buy |
| ACHEMBLOCK | T97985 | WP1066 98% | 1G | $215 | 2026-05-27 | Buy |
| ACHEMBLOCK | T97985 | WP1066 98% | 5G | $860 | 2026-05-25 | Buy |
| ACHEMBLOCK | T97985 | WP1066 98% | 5G | $860 | 2026-05-27 | Buy |
| AK Scientific | X5924 | WP1066 | 50mg | $252 | 2021-12-16 | Buy |
| AK Scientific | X5924 | WP1066 98%(HPLC) | 250mg | $99 | 2026-06-04 | Buy |
| AK Scientific | X5924 | WP1066 98%(HPLC) | 100mg | $60 | 2026-06-04 | Buy |
| AK Scientific | X5924 | WP1066 98%(HPLC) | 25mg | $21 | 2026-06-04 | Buy |
| American Custom Chemicals Corporation | KIN0001256 | WP1066 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001256 | WP1066 95.00% | 5MG | $698.02 | 2021-12-16 | Buy |
Properties
Melting point :90-93oC
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChIKey :VFUAJMPDXIRPKO-LQELWAHVSA-N
SMILES :Brc1nc(ccc1)\C=C(\C(=O)N[C@@H](C)c2ccccc2)/C#N
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChIKey :VFUAJMPDXIRPKO-LQELWAHVSA-N
SMILES :Brc1nc(ccc1)\C=C(\C(=O)N[C@@H](C)c2ccccc2)/C#N
Safety Information
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Description
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC50 = 5.6 μM) and U373-MG (IC50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Dideu Industries Group Limited
Hefei Hirisun Pharmatech Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
Nantong HI-FUTURE Biology Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
