ACPT-I
2物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1111
- 製品説明
- 英語製品説明ACPT-I
- 包装単位10mg
- 価格¥80000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1111
- 製品説明
- 英語製品説明ACPT-I
- 包装単位50mg
- 価格¥338000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01TOC1111 | ACPT-I |
10mg | ¥80000 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01TOC1111 | ACPT-I |
50mg | ¥338000 | 2024-03-01 | 購入 |
プロパティ
沸点 :440.4±45.0 °C(Predicted)
比重(密度) :1.651±0.06 g/cm3(Predicted)
貯蔵温度 :Desiccate at -20°C
溶解性 :Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
外見 :Powder
酸解離定数(Pka) :1.85±0.60(Predicted)
比重(密度) :1.651±0.06 g/cm3(Predicted)
貯蔵温度 :Desiccate at -20°C
溶解性 :Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
外見 :Powder
酸解離定数(Pka) :1.85±0.60(Predicted)
安全情報
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説明
ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.関連商品価格
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供給者とメーカー
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