| Company Name: |
OLON S.P.A.
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| Tel: |
?+39 02 9523.1 |
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?info@olonspa.it |
| Products Intro: |
Cas:127-07-1
ProductName:Hydroxycarbamide
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| Company Name: |
Chengdu Peter-like Biotechnology Co., Ltd.
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| Tel: |
028-81700200 13308200041 |
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2851167782@qq.com |
| Products Intro: |
Cas:127-07-1
ProductName:Hydroxycarbamide
Purity: NMR>=98% | Package: 5mg10mg20mg50mg100mg500mg1g2g等应客户需求包装
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| Company Name: |
Abcam Limited
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| Tel: |
021-2070050 400921018 |
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us.orders@abcam.com |
| Products Intro: |
Cas:127-07-1
ProductName:Hydroxyurea (Hydroxycarbamide), Ribonucleotide reductase inhibitor
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| | Hydroxycarbamide Chemical Properties |
| Melting point | 135-140 °C | | Boiling point | 136.04°C (rough estimate) | | density | 1.457±0.06 g/cm3(Predicted) | | refractive index | 1.4840 (estimate) | | storage temp. | 2-8°C | | solubility | H2O: 50 mg/mL | | form | powder | | pka | 10.56±0.23(Predicted) | | color | white | | Odor | odorless or almost odorless | | Water Solubility | soluble | | Merck | 14,4848 | | BRN | 1741548 | | Stability: | Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months. | | CAS DataBase Reference | 127-07-1(CAS DataBase Reference) | | IARC | 3 (Vol. 76) 2000 | | EPA Substance Registry System | Hydroxyurea (127-07-1) |
| Hazard Codes | T,Xn | | Risk Statements | 46-63-61-40 | | Safety Statements | 53-36/37-45-36-22 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | YT4900000 | | Hazard Note | Toxic | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29242100 | | Hazardous Substances Data | 127-07-1(Hazardous Substances Data) | | Toxicity | dog,LD50,intravenous,> 1gm/kg (1000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. |
| | Hydroxycarbamide Usage And Synthesis |
| Occurrence |
Hydroxycarbamide has been reported as endogenous in human blood plasma at concentrations of approximately 30 to 200 ng/ml.
| | Definition | Hydroxycarbamide is a chemotherapy treatment. It is also known as Hydrea. It was once also called Hydroxyurea.
| | Brand name |
Hydrea, Litalir, Droxia, and Siklos.
| | Mechanism of action |
Hydroxycarbamide is one of a group of chemotherapy drugs known as anti metabolites. These drugs stop cells making and repairing DNA Open a glossary item. Cancer cells need to make and repair DNA in order to grow and multiply.
| | Pharmacology | Hydroxyurea is a monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Similar to other antimetabolite anti-cancer drugs, it acts by disrupting the DNA replication process of dividing cancer cells in the body. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. | | Side effects |
Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches.There is also concern that it increases the risk of later cancers.Use during pregnancy is typically harmful to the fetus. Hydroxycarbamide is in the antineoplastic family of medications. It is believed to work by blocking the making of DNA.
| | Synthesis |
(1) add Urethylane at sodium hydroxide solution, then drip aqueous hydroxylamine, after dropwising, carry out condensation reaction;
(2) react rear hydrochloric acid and adjust pH7-8; Suction filtration while hot after 58 ~ 62 DEG C of underpressure distillation go out the water of 70 ~ 80% afterwards; Then holding temperature 58 ~ 62 DEG C, joins filtrate in resin cation (R.C.) and decolours;
(3), after decolouring, suction filtration is carried out; Then when filtrate is cooled to 0 ~ 5 DEG C, insulation crystallization; And then carry out suction filtration, filter cake 0-5 DEG C of cold water washing twice; With the use gauge of azanol, the consumption washing material water for the 1st time is 0.8 ~ 1.0ml/g, and the consumption washing material water for the 2nd time is 0.6 ~ 0.8ml/g; Hydroxycarbamide product is obtained finally by drying.
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| | Hydroxycarbamide Preparation Products And Raw materials |
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