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Barnidipine Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Products Intro: Product Name:(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Purity:0.99 Package:5KG;1KG Remarks:C27H29N3O6
Company Name: BOC Sciences
Tel: +16314854226
Products Intro: Product Name:Barnidipine-[d5]
Purity:>95% Package:5mg Remarks:BOC Sciences also provides custom synthesis services for Barnidipine-[d5].
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Products Intro: Product Name:Barnidipine
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-30859
Tel: +8618523575427
Products Intro: Product Name:barnidipine
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Products Intro: Product Name:(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Purity:85.0-99.8% Package:1KG;1USD

Barnidipine manufacturers

  • Barnidipine USP/EP/BP
  • Barnidipine USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-08-07
  • CAS:104713-75-9
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • Barnidipine
  • Barnidipine pictures
  • $0.00 / 1KG
  • 2020-05-12
  • CAS:104713-75-9
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 500 MT
Barnidipine Basic information
Product Name:Barnidipine
Synonyms:BARNIDIPINE;(4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3S)-1-benzylpyrrolidin-3β-yl] ester;(4S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester;(4S)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-methyl 3-[(3S)-1-benzylpyrrolidin-3-yl] ester;(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;(+)-(3'S,4S)-1-Benzyl-3-pyrrolidinyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;(S)-3-((S)-1-Benzylpyrrolidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3;(S)-3-((S)-1-Benzylpyrrolidin-3-yl)-5-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin
Product Categories:API
Mol File:104713-75-9.mol
Barnidipine Structure
Barnidipine Chemical Properties
Melting point 137-139°
alpha D20 +64.8° (c = 1 in methanol)
Boiling point 614.5±55.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO
Safety Information
MSDS Information
Barnidipine Usage And Synthesis
DescriptionBarnidipine is a long-acting novel calcium antagonist that belongs to the dihydropyridine (DHP) group of calcium channel blockers. It contains two chiral centres thus can have four possible enantiomers. The active component is composed of a single optical isomer (3'S, 4S configuration), which is the most potent and longest-acting of the four enantiomers. Barnidipine has shown to be an effective antihypertensive agent in the management of hypertension in elderly patients and its efficacy is not negatively affected by age.
UsesBarnidipine is used in the treatment of hypertension, barnidipine displays high affinity for the calcium channels of the smooth muscle cells in the vascular wall and selectivity against cardiovascular L-type calcium channels.
DefinitionChEBI: Barnidipine is a dihydropyridine.
Manufacturing ProcessIn 5 ml of isopropyl alcohol were dissolved 1.5 g (0.01 mole) of 3- nitrobenzaldehyde, 2.6 g (0.01 mole) of 1-benzyl-3-acetoacetyloxypyrrolidine, and 1.3 g (0.01 mole) of β-aminocrotonic acid methyl ester and then the solution was refluxed for 8 hours. The solvent was distilled off under reduced pressure, the residue obtained was dissolved in a small amount of chloroform, and the solution was applied to silica gel column chromatography (column diameter 1.5 cm, height 20 cm, and about 200 ml of chloroform was used as the eluent). The eluates were collected and concentrated to give 3.4 g of oily 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3- (1-benzylpyrrolidin-3-yl)ester-5-methyl ester: [α]D 20=+64.8° (c = 1 in methanol).
Therapeutic FunctionCoronary vasodilator
Side effectsThe side effects of barnidipine are typically mild to moderate and typically occur at the beginning of treatment. Common side effects include nausea, palpitations, flushed face, hot flashes, swelling, headache, heavy sensation in the head, dizziness, and a feeling of unsteadiness. Other reported side effects include redness, rash, itching, and sensitivity to sunlight.
PrecautionsThe medicine may cause dizziness, etc. due to decreased blood pressure. Pay close attention when you work at heights, drive a car or operate dangerous machinery.
Since intake of grapefruit juice may enhance the effect of the medicine, refrain from drinking it.
References[1] LIAUCHIAU-SUONG. Barnidipine: a new calcium channel blocker for hypertension treatment.[J]. Expert Review of Cardiovascular Therapy, 2005. DOI:10.1586/14779072.3.2.207.
[2] CHENGZHI-GANG. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance.[J]. Molecules, 2014. DOI:10.3390/molecules19011344.
[4] DEROSAGIUSEPPE. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus.[J]. BMC Cardiovascular Disorders, 2016. DOI:10.1186/s12872-016-0237-z.
Barnidipine Preparation Products And Raw materials
Raw materials1-BENZYL-3-ACETOACETYLOXYPYRROLIDINE-->3-Nitrobenzaldehyde
Preparation ProductsBarnidipine hydrochloride
Tag:Barnidipine(104713-75-9) Related Product Information
Barnidipine-d4 Barnidipine-d5 HCl 3-BUTOXYPYRROLIDINE 3-PROPOXYPYRROLIDINE Benzyl isocyanate (R)-(-)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Monomethyl Ester 2,5-Dimethylpyrrolidine Nicardipine 2-(Diethylamino)ethyl methacrylate (S)-1-Benzyl-3-pyrrolidinol (S)-(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Monomethyl Ester METHYL-2-PYRROLIDONE N-Benzyl-3-pyrrolidinol (-)-Nitrendipine ETHOXYPYRROLIDINE(S-3-) Benzyl (S)-3-METHOXYPYRROLIDINE Benzyl nicotinate