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CGS 21680A

CGS 21680A Suppliers list
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008657128800458; +8615858145714
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Products Intro: Product Name:4-[2-[[6-Amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid monohydrochloride (Fandachem)
CAS:124431-80-7
Purity:As coa Package:As request Remarks:124431-80-7
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:CGS 21680 HCl
CAS:124431-80-7
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:CGS 21680A
CAS:124431-80-7
Purity:0.99 Package:5KG;1KG
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:CGS 21680A
CAS:124431-80-7
Purity:52799% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:CGS 21680A
CAS:124431-80-7
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
CGS 21680A Basic information
Product Name:CGS 21680A
Synonyms:CGS 21680 (HCl salt);CGS 21680A;4-[2-[[6-Amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid monohydrochloride;Benzenepropanoic acid, 4-[2-[[6-amino-9-(N-ethyl-b-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]- hydrochloride (1:1);[3H]-CGS 21680A;CGS 21680A;CGS 21680 HCL;CGS 21680 HCl NEW;100688
CAS:124431-80-7
MF:C23H30ClN7O6
MW:535.99
EINECS:
Product Categories:Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File:124431-80-7.mol
CGS 21680A Structure
CGS 21680A Chemical Properties
Melting point 204-206°C
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form Solid
color White to Light Beige
Stability:Hygroscopic
CAS DataBase Reference124431-80-7
Safety Information
MSDS Information
CGS 21680A Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
UsesAdenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).
UsesA selective A2A receptor agonist.
UsesCGS 21680A is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM). It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 μM, respectively) and is without effect at adenosine A2B (Ki > 10 μM). CGS 21680A is commonly used to study the actions of the adenosine A2A receptor in cells and tissues.[Cayman Chemical]
Biological Activitycgs 21680 hcl is a selective agonist of a2 adenosine receptor with ic50 value of 22nm [1].in rat striatal membranes, cgs 21680 potently prevents ligands from binding to a2 adenosine receptors with ic50 value of 22nm. in the binding assay, cgs 21680 shows no effect to other putative neurotransmitter/neuromodulator sites in brain membranes such as adrenergic, dopamine and serotonin. in the rat heart model, cgs 21680 is effective in increasing coronary flow with ec25 value of 2nm [1].
in vivothe hydrochloride salt of cgs 21680 has potent efficacy to decrease blood pressure in the anesthetized normotensive rat with ed50 value of 9μg/kg. it also causes heart rate increasing up to 15%. besides that, cgs 21680 hcl significantly lower the blood pressure at dose of 10mg/kg in the spontaneously hypertensive rat. a transient elecation of heart rate is also observed at 30 min in the model [1].
storage-20°C (desiccate)
references[1] hutchison a j, webb r l, oei h h, et al. cgs 21680c, an a2 selective adenosine receptor agonist with preferential hypotensive activity. journal of pharmacology and experimental therapeutics, 1989, 251(1): 47-55.
CGS 21680A Preparation Products And Raw materials
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