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| | Chloromethyl isopropyl carbonate Basic information |
| | Chloromethyl isopropyl carbonate Chemical Properties |
| Boiling point | 66 °C(Press: 16 Torr) | | density | 1.14 | | refractive index | 1.4110-1.4150 | | Fp | 50° | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly) | | form | clear liquid | | color | Colorless to Almost colorless | | Stability: | Moisture sensitive | | InChI | InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3 | | InChIKey | JHYNXXBAHWPABC-UHFFFAOYSA-N | | SMILES | C(OC(C)C)(=O)OCCl | | CAS DataBase Reference | 35180-01-9(CAS DataBase Reference) |
| Safety Statements | 24/25 | | RIDADR | 2924 | | HazardClass | 3/8 | | PackingGroup | Ⅲ | | HS Code | 29189900 |
| | Chloromethyl isopropyl carbonate Usage And Synthesis |
| Chemical Properties | Clear Colourless Liquid | | Uses | Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent. | | Synthesis | At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.
| | References | [1] Tetrahedron, 2011, vol. 67, # 29, p. 5319 - 5328
[2] Patent: JP2015/164934, 2015, A. Location in patent: Paragraph 0195
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 771 - 778
[4] Patent: WO2004/92189, 2004, A1. Location in patent: Page 29
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153 |
| | Chloromethyl isopropyl carbonate Preparation Products And Raw materials |
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