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Tenofovir

Tenofovir Suppliers list
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:0KG;0USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:98% Min. Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:880/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Tenofovir
CAS:147127-20-6
Purity:99% Package:1000KG;;100KG;10KG;5KG;1KG

Lastest Price from Tenofovir manufacturers

  • Tenofovir
  • US $100.00 / KG
  • 2018-07-27
  • CAS:147127-20-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: Customized
  • Tenofovir
  • US $200.00 / KG
  • 2018-07-26
  • CAS:147127-20-6
  • Min. Order: 100G
  • Purity: 98%
  • Supply Ability: 10KG,20KG
  • Tenofovir
  • US $130.00 / G
  • 2018-07-25
  • CAS:147127-20-6
  • Min. Order: 1G
  • Purity: 99%
  • Supply Ability: 1kg
Tenofovir Basic information
Indications and Usage Mechanisms of Action Pharmacokinetics Adverse Effects
Product Name:Tenofovir
Synonyms:(R)-(1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methylphosphonic acid;Tenofovir (PMPA);Tenofovir(Viread);[[(1R)-2(6-AMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]ph;Viread;1-(6-AMinopurin-9-yl)propan-2-yloxyMethylphosphonic acid(PMPA);Tenofovir 1-(6-Aminopurin-9-yl)propan-2-yloxymethylphosphonic acid;R-PMPA, Tenofovir,
CAS:147127-20-6
MF:C9H14N5O4P
MW:287.21
EINECS:604-571-2
Product Categories:Inhibitors;Purine;ACTIVE PHARMACEUTICAL INGREDIENTS;Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File:147127-20-6.mol
Tenofovir Structure
Tenofovir Chemical Properties
Melting point 276-280°C
alpha D +21° (c = 1 in 0.1M HCl)
storage temp. Store at -20°C
form powder
color white to beige
optical activity[α]/D -20 to -26°, c = 0.5 in 1 M HCl
Water Solubility 13.4 mg/mL (25 ºC)
Merck 14,9146
CAS DataBase Reference147127-20-6(CAS DataBase Reference)
Safety Information
RTECS SZ6563600
HS Code 29339900
MSDS Information
Tenofovir Usage And Synthesis
Indications and UsageTenofovir disoproxil (Viread) is the first nucleotide analogue approved by the American FDA to treat HIV-1 infections. Tenofovir disoproxil is a drug used in the AIDS cocktail treatment method, and research shows that it has the ability to increase monkeys’ immunity to immunodeficiency viruses (similar to the human AIDS virus). Tenofovir disoproxil is used in combination with other reverse transcriptase inhibitors to treat HIV-1 infections and hepatitis B.
Mechanisms of ActionTenofovir disoproxil is an acyclic nucleoside antivirus drug and has an inhibiting effect on HBV multi-enzyme complexes and HIV reverse transcriptase. Its active content tenofovir phosphonate directly competitively binds to natural deoxyribose substrate to inhibit the virus multi-enzyme complex and inserts itself into the DNA to end the nucleotide chain. Tenofovir disoproxil is barely absorbed by the gastrointestinal duct, so it undergoes esterification and ionization to become tenofovir ester fumarate. Tenofovir is soluble in water and can be quickly absorbed and decomposed into the active substance tenofovir, which then transforms into the active metabolite tenofovir phosphonate. As this drug is not metabolized by the CYP450 enzyme system, it has a very low chance of drug interactions caused by this enzyme.
PharmacokineticsTenofovir disoproxil reaches peak blood concentration 1-2 hours after intake. Tenofovir disoproxil’s bioavailability increases by about 40% when taken with food. The intracellular half-life of tenofovir phosphonate is about 10 hours, so doses can be taken once daily. This drug is mainly filtered through renal glomeruli and excreted through the renal tubule transport system, with 70-80% excreted in its original form through urine.
Adverse Effects
  • Weakness and exhaustion.
  • Mild to moderate gastrointestinal reactions, including diarrhea, stomach pain, nausea, vomiting, bloating, lactic acid poisoning, hepatomegaly and fatty liver, and pancreatitis. These adverse reactions also commonly appear individually or combined when taking nucleoside analogues.
  • Metabolic system hypophosphatemia (1% occurrence rate).
  • Fat accumulation and redistribution, including centripetal obesity, buffalo hump, thin limbs, breast growth, and Cushing syndrome.
  • May cause lactic acid poisoning, hepatomegaly related to steatosis, etc.
  • Effects on nervous system: dizziness and headache.
  • Effects on respiratory system: difficulty breathing.
  • Effects on skin: drug rash.
Chemical PropertiesWhite Crystalline Solid
UsesTenofovir is a drug used for the treatment of chronic heptatitis B as well as prevention and treatment of HIV/AIDS. It is a kind of nucleotide analog, acting as the reverse-transcriptase inhibitor (NtRTI). It inhibits the activity of HIV reverse transcriptase through competing with the natural substrate deoxyadenosine 5’-triphosphate, causing the termination of DNA chain. 
DefinitionChEBI: A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxy ethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Acquired resistanceHIV variants with the K65R mutation and the K70E mutation in the reverse transcriptase demonstrate reduced susceptibility to tenofovir.
Pharmaceutical ApplicationsA nucleotide analog structurally similar to adefovir.
EC50 values for HBV, assessed in the HepG2 2.2.15 cell line, ranged from 0.14 to 1.5 μm; the cytotoxic concentration exceeded 100 μm. A decline in HBV DNA levels below 105 copies/mL at 48 weeks of therapy in 100% of patients receiving tenofovir compared with 44% on adefovir therapy has been reported. There are also case reports of patients with primary resistance to adefovir responding to tenofovir.
It is generally well tolerated in patients with chronic HBV; the most common side effects include nausea and gastrointestinal upset, headache, dizziness, fatigue and rash.
Pharmaceutical ApplicationsAn acyclic nucleoside phosphonate, formulated as the disoproxil fumarate salt for oral administration.
Biological ActivitySelectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC 50 = 1.5 μ M). Antiviral agent.
PharmacokineticsOral absorption: c. 25%
Cmax 300 mg once daily: 0.3 mg/L
Plasma half-life: 17 h
Volume of distribution: 1.3 ± 0.6 L/kg at 3.0 mg/kg intravenous dose
Plasma protein binding: <0.7% (in vitro)
Absorption and distribution
Oral bioavailability is poor, but is enhanced by administration as the disoproxil prodrug. It may be taken with or without food. CSF penetration is likely to be minimal due to the anionic charge of the molecule at physiological pH. It accumulates in semen at higher concentrations than in plasma. It is not known if it is distributed into breast milk.
Metabolism and excretion
Tenofovir is not metabolized and is principally eliminated by the kidneys by a combination of glomerular filtration and active tubular secretion. In patients with renal dysfunction the dose should be adjusted accordingly.
Compounds such as cidofovir, aciclovir (acyclovir), valaciclovir, ganciclovir, valganciclovir and probenecid may compete for renal excretion. Tenofovir levels are increased when prescribed with some HIV protease inhibitors. The co-administration of tenofovir with didanosine leads to didanosine accumulation which is thought to occur through inhibition of purine nucleoside phosphorylase. This has been associated with impaired immune recovery and several cases of lactic acidosis and pancreatitis. If tenofovir is combined with didanosine the dose of didanosine should be reduced to 200 mg (<60 kg) or 250 mg (≥60 kg) per day and the patient monitored for symptoms of didanosine toxicity.
Clinical UseChronic hepatitis B infection
Clinical UseTreatment of HIV infection in adults and children (in combination with other antiretroviral drugs)
Side effectsIn clinical trials of antiretroviral treatment-naive participants, the most commonly reported adverse events were mild to moderate gastrointestinal upset (nausea 8%, diarrhea 11%), headache (14%) and depression (11%). Tenofovir has the potential to result in nephrotoxicity, particularly through proximal tubular damage, but the risk of clinically significant renal dysfunction appears relatively low and seems to occur mainly in subjects with other identifiable risks for renal impairment. Minor elevations in serum creatinine and reductions in creatinine clearance occur, but rarely require drug discontinuation.
A few (<0.1%) cases of osteomalacia and decreased bone density have been reported.
Tenofovir Preparation Products And Raw materials
Tag:Tenofovir(147127-20-6) Related Product Information
Chloromethyl isopropyl carbonate Diethyl (tosyloxy)methylphosphonate CHLOROMETHYL CHLOROFORMATE (JMC)(INTERMEDIATE OF TENOFOVIR DISOPROXIL FUMARATE) TENOFOVIR MONOPHOSPHATE TENOFOVIR, [8-14C]- TENOFOVIR DIPHOSPHATE Tenofovir Phosphate, >60% Intermediate For Tenofovir Tenofovir Adefovir PROPANE Tenofovir disoproxil Guaiacol Anisole ISOPROPYLPHENYLDIPHENYL PHOSPHATE Adenine (Trifluoromethoxy)benzene 4-Methoxyphenol