|
|
| | N-Boc-6-methoxyindole Basic information | | Synthesis |
| Product Name: | N-Boc-6-methoxyindole | | Synonyms: | 1H-Indole-1-carboxylicacid,6-hydroxy-,1,1-diMethylethylester;6-Hydroxyindole, N-BOC protected 95%;tert-butyl 6-hydroxyindole-1-carboxylate;1-Boc-indol-6-ol;TERT-BUTYL 6-HYDROXY-1H-INDOLE-1-CARBOXYLATE | | CAS: | 898746-82-2 | | MF: | C13H15NO3 | | MW: | 233.26 | | EINECS: | | | Product Categories: | | | Mol File: | 898746-82-2.mol |  |
| | N-Boc-6-methoxyindole Chemical Properties |
| Boiling point | 374.5±34.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 9.48±0.40(Predicted) | | Appearance | White to light yellow Solid |
| | N-Boc-6-methoxyindole Usage And Synthesis |
| Synthesis | Tert-butyl 6-fluoro-5-hydroxy-1H-indazole-1-carboxylate was prepared as
described for intermediate tert-butyl 5-hydroxy-1H-indazole-1-carboxylate/ tert-butyl 5-hydroxy-2H-indazole-2-
carboxylate replacing tert-butyl 5-((tert-butyldimethylsilyl)oxy)-1H-indazole-1-carboxylate / tert-butyl 5-((tertbutyldimethylsilyl)
oxy)-2H-indazole-2-carboxylate with tert-butyl 5-((tert-butyldimethylsilyl)oxy)-6-fluoro-1H-indazole-1-carboxylate(yield: 94%). 1H
NMR (400 MHz, Chloroform-d) δ 8.06 (d, J = 0.9 Hz, 1H), 7.95 (d, J = 10.7 Hz, 1H), 7.28 (d, J
= 8.2 Hz, 2H), 5.48 (s, 1H), 1.71 (s, 9H). | | References | [1] Patent: CN107188900, 2017, A. Location in patent: Paragraph 0104; 0105; 0106 |
| | N-Boc-6-methoxyindole Preparation Products And Raw materials |
|